Document 3091
 DOCN  M94A3091
 TI    Cellular and serological activation markers including sICAM 1 in
       long-term observations.
 DT    9412
 AU    Schoenwald E; Duschet P; Marhold I; Gschnait F; Dermat. Depart.,
       Hospital of Lainz, Vienna, Austria.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):156 (abstract no. PB0052). Unique
       Identifier : AIDSLINE ICA10/94369484
 AB    OBJECTIVE: Determination of the correlation of cellular and serological
       parameters including sICAM 1 by long term analysis from HIV positive non
       progressors versus progressors to AIDS. METHODS: 44 patients were
       studied at 512 visits (mean: 11), 15 patients developed AIDS within the
       observation period (1-73 months, mean 26) (progr.), 29 remained stable
       (non progr.). Parameters measured: ELISA: sICAM 1, beta 2-microglobulin
       (beta 2m), serum neopterin; flow cytometry: CD4+, CD8+38+, CD3+HLADR+.
       Statistics: Comparison of parameters at enrollment, during observation
       period and at the end of the follow up (Wilcoxon, Mann-Whitney),
       rankcorrelation of sICAM 1 with all parameters (Spearman). RESULTS:
       sICAM 1 displayed significant correlation with beta 2m (p < 0.01) and
       CD8+38+ (p < 0.001). Comparison of the initial visit (progr. vs. non
       progr.) showed differences only within the CD4+ (p < 0.01) and the
       CD8+38+ (p < 0.05) cells. Long term observations of non progr. showed
       distinct changes of CD8+38+ (p < 0.05), whereas the other parameters
       remained stable. Observation of progr. demonstrated clear shifts of all
       parameters. CONCLUSIONS: Among the growing number of cellular and
       serological factors, currently investigated for their predictive value
       in the natural course of HIV-infection, low CD4+ numbers and high
       CD8+38+ values seem to have the most importance. The definite value of
       sICAM 1, beeing enhanced and correlating well to beta 2m and CD8+38+,
       for the prediction of the clinical course is not yet clear.
 DE    beta 2-Microglobulin/ANALYSIS  Acquired Immunodeficiency
       Syndrome/*BLOOD/IMMUNOLOGY/  PHYSIOPATHOLOGY  Antigens, CD/*BLOOD
       Antigens, CD3/BLOOD  Antigens, CD4/BLOOD  Antigens, CD8/BLOOD  Antigens,
       Differentiation/BLOOD  Biological Markers/BLOOD  Cell Adhesion
       Molecules/*BLOOD  Comparative Study  Enzyme-Linked Immunosorbent
       Assay/METHODS  Follow-Up Studies  Human  HIV
       Seropositivity/*BLOOD/IMMUNOLOGY/PHYSIOPATHOLOGY  HLA-DR Antigens/BLOOD
       Predictive Value of Tests  Time Factors  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).