Document 3094
 DOCN  M94A3094
 TI    CD4 lymphocyte depletion: correlation with P24 antigen, neopterin, beta
       2 microglobulin, CD8 count.
 DT    9412
 AU    Salvato P; Thompson C; Houston Immunological Institute, Texas.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):155 (abstract no. PB0047). Unique
       Identifier : AIDSLINE ICA10/94369481
 AB    OBJECTIVE: To describe laboratory markers as related to CD4 cell decline
       in HIV disease progression. METHODS: 114 HIV+ pts. underwent lab.
       testing for CD4 count, P24 antigen, neopterin, beta 2 microglobulin and
       CD8 count. A chart review was conducted to determine length of known
       exposure based upon high-risk sexual activity, date of blood/blood
       product transfusion, known needle stick, or needle sharing, and
       HIV-negative testing prior to actual seroconversion. RESULTS: (17 pts.
       excluded: length of exposure not accurately determined). TABULAR DATA,
       SEE ABSTRACT VOLUME. CONCLUSIONS: CD4 lymphocyte depletion is the
       hallmark of HIV disease progression. Changes in other lab. markers also
       appear predictable over time. Loss of CD4 cells results in increased CD8
       cells until late in disease. Neopterin levels increase earlier in the
       disease process than beta 2 microglobulin, although both increase with
       disease progression. Early in disease P24 can be detected; P24 activity
       tends to increase with disease progression. Combinations of these lab.
       markers can enhance testing confidence and may facilitate patient
       counseling, treatment modifications, and selection of study end points.
 DE    beta 2-Microglobulin/ANALYSIS  Biological Markers/BLOOD
       Biopterin/*ANALOGS & DERIVATIVES/BLOOD  Blood Transfusion  *CD4-CD8
       Ratio  Human  HIV Core Protein p24/*BLOOD  HIV
       Infections/BLOOD/IMMUNOLOGY/*PHYSIOPATHOLOGY  HIV
       Seropositivity/BLOOD/IMMUNOLOGY/*PHYSIOPATHOLOGY  Needle Sharing
       Needlestick Injuries  Predictive Value of Tests  Sex Behavior  Time
       Factors  T4 Lymphocytes/*IMMUNOLOGY  MEETING ABSTRACT

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