Document 3097
 DOCN  M94A3097
 TI    Longitudinal immunophenotypic studies on a cohort of asymptomatic HIV+ve
       patients.
 DT    9412
 AU    Trickett A; Tesfamariam N; Dwyer J; Kwan YL; St. George Hospital,
       Sydney, Australia.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):154 (abstract no. PB0043). Unique
       Identifier : AIDSLINE ICA10/94369478
 AB    OBJECTIVE: To study the changing proportions of subsets of CD4 and CD8
       cells over time in a cohort of asymptomatic HIV+ve patients. This work
       is being undertaken to aid in delineation of disease progression.
       METHODS: Blood samples obtained at yearly intervals from 21 patients
       were stained for 3 colour immunofluorescence. Control blood was obtained
       from 21 age matched subjects at low risk for HIV. The following
       combinations of antibodies were used: CD3/CD4/CD56/CD8; HLA-DR/CD38/CD8;
       CD45RA/CD45RO/CD8; TCR alpha beta/TCR gamma delta. RESULTS: % of
       lymphocytes binding antibody: TABULAR DATA, SEE ABSTRACT VOLUME.
       CONCLUSION: The phenotypic profile of CD4 and CD8 subsets change with
       time. For example, a decrease in the number of CD8+/CD45RA+/CD45RO+ was
       noted. Increased expression of the activation markers HLA-DR and CD38
       occur early in the course of infection and persist. Such changes may
       have progostic significance. Studies are ongoing.
 DE    Antigens, CD/*BLOOD  Cohort Studies  Comparative Study  CD4-CD8 Ratio
       Human  HIV Seronegativity/*IMMUNOLOGY  HIV Seropositivity/*IMMUNOLOGY
       *Immunophenotyping  Killer Cells, Natural/IMMUNOLOGY  Longitudinal
       Studies  Receptors, Antigen, T-Cell, alpha-beta/ANALYSIS  Receptors,
       Antigen, T-Cell, gamma-delta/ANALYSIS  T-Lymphocyte Subsets/*IMMUNOLOGY
       MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).