Document 3102
 DOCN  M94A3102
 TI    Gender differences in infectious HIV viral burden among injecting drug
       users. ALIVE Study.
 DT    9412
 AU    Farzadegan H; Vlahov D; Nelson K; Johns Hopkins University, Baltimore,
       MD 21205.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):153 (abstract no. PB0040). Unique
       Identifier : AIDSLINE ICA10/94369473
 AB    OBJECTIVE: To compare infectious viral load among men and women IDUs.
       METHOD: A total of 285 IDUs, of whom 89 (31%) were women at various CD4
       levels were studied. (Median CD4 = 394 range 2-2375). Infectious viral
       load was determined by cocultivation of serial 5-fold dilution of one
       million PBMC, with normal PBMC (IUPM). CD4 lymphocyte phenotyping was
       performed using 2 color flow cytometric measurements. RESULTS: The
       median IUPM was 8. The proportion of men and women with IUPM greater or
       less than 8 IUPM (medium) was similar in IDUs with CD4 count greater
       than 400. Among IDUs with CD4 less than 400, 73% (74/101) of men and 58%
       (25/43) women had IUPM > or = 8 (P = 0.07). Multiple logistic regression
       analysis found CD4 level less than 400 was significantly associated with
       IUPM > or = 8 (P = 0.0001). However gender was not independently
       significant (P = 0.1). CONCLUSION: Viral load was significantly higher
       in IDUs with low CD4 level but similar between male and female IDUs
       after controlling for CD4 level.
 DE    Antigens, CD/BLOOD  Antigens, CD4/BLOOD  Cells, Cultured  Comparative
       Study  Female  Human  HIV/*ISOLATION & PURIF  HIV
       Infections/*IMMUNOLOGY/MICROBIOLOGY
       Lymphocytes/IMMUNOLOGY/*MICROBIOLOGY  Male  *Sex Characteristics  Sex
       Factors  Substance Abuse, Intravenous/IMMUNOLOGY/*MICROBIOLOGY  T4
       Lymphocytes/*IMMUNOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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