Document 3114
 DOCN  M94A3114
 TI    CD8 hyperlymphocytosis in 17 HIV patients.
 DT    9412
 AU    Coutellier A; Autran B; Cherin P; Debre P; Herson S; Sce de Medecine
       Interne, G.H. Pitie Salpetriere, Paris,; France.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):150 (abstract no. PB0025). Unique
       Identifier : AIDSLINE ICA10/94369461
 AB    A CD8 hyperlymphocytosis is observed in 5 to 10% of HIV infected
       patients. It has been related to a diffuse visceral infiltration: The
       SICCA syndromee whose clinical observation can be compared to the
       Gougerot-Sjogren one. Its pronostic value is not clearly established.
       Seventeen HIV 1 seropositive patients (15 male and 2 female) showing a
       persistant CD8 hyperlymphocytis (more than 1200/mm3 circulating CD8 rate
       during more than 3 months) have been studied. 7 patients presented an
       opportunist infection in spite of high CD4 rates (> 400/mm3). The
       research of a CD8 visceral infiltration by salivary glands biopsy ocular
       examination, and broncho-alveolar lavage, was done in 5 patients. No
       infiltration syndrome has been found. Only one patient showed a CD8
       lymphocytary alveolite without phenotypic particularity. The blood
       lymphocytes phenotypes of 17 patients were studied. In CD4 population
       there is an imbalance between the CD4 + CD45RA + (memory cells) which
       have increased and the CD4 + CD45RA +C (virgin cells) which have
       decreased. In CD8 population, we found an hyperactivation similar the
       one existing in seropositive patients without CD8 hyperlymphocytosis.
       The dosage of interleukines IL2, IL4, IL6, TNF alpha and gamma
       interferon, done in 6 patients is normal. The study of the lymphocytes
       function effected in 5 patients shows an absence or diminution of the T
       proliferative response to soluble tuberculine; streptococcic and CMV
       antigenes and to Pokeweed Mitogen (PKW) constrasting with the
       persistance of responses to MLR and PHA. In conclusion: The existence of
       a major CD8 hyperlymphocytosis is not always correlated to the existence
       of a visceral CD8 infiltration syndrome. CD8 hyperlymphocytis seems to
       be at the origine of an imbalance of the different CD4 sub-population
       with an increase of the memory cells and a functionnel deficit to the T
       proliferative response, responsible for an actual immunodepression not
       correlated to the CD4 numbers. The HIV patients with CD8
       hyperlymphocytose may show opportunist infections as a result of the
       functional deficit of the auxillary T cells independantly from the
       absolute CD4 number and this must raise the question of the indication
       of an antiretroviral treatment.
 DE    Antigens, CD/*ANALYSIS  Antigens, CD8/*ANALYSIS  Female  Human  HIV
       Infections/*IMMUNOLOGY  HIV Seropositivity/*IMMUNOLOGY  *HIV-1
       Immunophenotyping  Lymphocyte Culture Test, Mixed  Lymphocyte
       Transformation  Lymphocytosis/*IMMUNOLOGY  Male  Salivary
       Glands/IMMUNOLOGY/PATHOLOGY  T-Lymphocytes/IMMUNOLOGY  MEETING ABSTRACT

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