Document 3122
 DOCN  M94A3122
 TI    Herpesvirus antibodies levels in HIV2 positive population.
 DT    9412
 AU    Marques A; Palminha P; Graca A; National Institute of Health, Lisbon,
       Portugal.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):149 (abstract no. PB0024). Unique
       Identifier : AIDSLINE ICA10/94369453
 AB    The importance of Herpesvirus (Epstein-Barr Virus, Citomegalo Virus,
       Herpes Simplex Virus, Varicella zoster Virus) infections in the acquired
       immunodeficiency syndrome is not well established. A study of the
       serological profiles against Herpesvirus was carried out in HIV2 samples
       of patients attending an out-patient clinic. Forty-two HIV2 positives
       cases were distributed by signs and symptoms; 27 (64%) asymptomatic, 15
       (36%) symptomatic. The distribution by race and sex showed that 28 (67%)
       black, 14 (33%) caucasian, 27 (64%) males, 15 (36%) females. The
       following age groups were identified, 10-19 years 2 cases (5%), 20-29
       years 10 cases (24%), 30-39 years 7 cases (17%), 40-49 years 15 cases
       (37%), 50-59 years 4 cases (10%) and over 60 years 3 cases (7%). At the
       Laboratory of Virology of the National Institute of Health sera samples
       were titrated using the indirect immunofluorescence assays. Most sera
       had IgG anti-EBV antibodies (96%), IgG anti-CMV antibodies (93%), IgG
       anti-HSV antibodies (100%), IgG anti-VZV antibodies (95%) and all the
       96% IgG anti-EBV had IgG anti-Epstein-Barr Nuclear Antigen (EBNA)
       positives. Concerning the IgM antibodies we found two cases of IgM
       anti-EBV positives and one case of IgM anti-CMV positive. High titres
       were observed for the following virus: EBV, 1/160 12 cases (29%), 1/320
       16 cases (38%), 1/640 7 cases (17%): CMV, 1/40 12 cases (29%), 1/80 13
       cases (31%), 1/160 8 cases (19%); HSV, 1/160 17 cases (41%), 1/320 16
       cases (38%), 1/640 7 cases (17%); VZV 1/20 9 cases (21%), 1/40 15 cases
       (36%), 1/80 11 cases (28%). The two cases of IgM anti-EBV antibodies
       positives, one had a IgG titre 1/160 and the other had a IgG titre
       1/320. The case with IgM anti-CMV antibodies positives had a IgG titre
       1/160. We found higher titres for the antibodies anti-EBV and anti-HSV
       than those found in the portuguese population in general. Additionally
       the titres of IgG antibodies anti-CMV and anti-VZV were similar to those
       found in the general population. In summary we don't know if the
       presence of high levels of these antibodies for the EBV and HSV are due
       to the reactivation of the virus or are markers or cofactors in the
       development of severe disease.
 DE    Acquired Immunodeficiency Syndrome/BLOOD/*IMMUNOLOGY  Adolescence  Adult
       Antibodies, Viral/*BLOOD  Child  Comparative Study
       Cytomegalovirus/*IMMUNOLOGY  Female  Herpesvirus 4, Human/*IMMUNOLOGY
       Human  HIV Seropositivity/BLOOD/*IMMUNOLOGY  *HIV-2  IgG/BLOOD
       IgM/BLOOD  Male  Middle Age  Portugal  Simplexvirus/*IMMUNOLOGY  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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