Document 3123
 DOCN  M94A3123
 TI    Evidence of an in vitro association of HIV with other DNA viruses.
 DT    9412
 AU    Cisterna R; Campelo C; Gorrino MT; Malave C; Sarria L;
       Fernandez-Aranguiz A; Lardelli P; Sunen E; Madariaga L; Immunology,
       Microbiology and Parasitology Dept. University of the; Basque Country,
       Spain.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):149 (abstract no. PB0023). Unique
       Identifier : AIDSLINE ICA10/94369452
 AB    Several authors have focused their attention on the possibility that
       cofactors may be important in the pathogenesis of acquired
       immunodeficiency syndrome (AIDS). To investigate the association of
       Human Immunodeficiency Virus (HIV) with various DNA viruses e.g.
       Hepatitis B Virus (HBV), Citomegalovirus (CMV) and Epstein-Barr Virus
       (EBV), simultaneous determinations of HIV p24 antigen (HIVp24Ag), HBV
       surface antigen (HBsAg) and DNA, CMV DNA and EBV DNA were performed in
       lymphocyte culture supernatants from 54 individuals at risk of HIV
       infection. In 25 patients all viral determinations cited above could be
       done: in 10 patients, simultaneous expression of all viruses was
       detected, 12 patients resulted negative for expression of all viruses
       and 3 resulted positive for some other virus in absence of HIVp24Ag. In
       29 patients determination of all viruses was not possible: 14 were
       positive for HIVp24Ag expression and in all of them simultaneous
       expression of some other virus was detected, 15 were HIVp24Ag negative
       in culture supernatants but in 13 of them some other viral expression
       was always detected being only the remaining 2 patients negative for all
       other virus tested. Thus, HIV expression in lymphocyte culture
       supernatants never occurred alone as expression of some other virus was
       always detected in the 24 patients expressing HIV antigen in vitro from
       the 54 patients tested. Furthermore, 16 patients were positive for the
       determination of some other viral expression in the absence of HIV
       expression and 14 were negative for all viruses tested.
 DE    Cells, Cultured  DNA Viruses/*ISOLATION & PURIF  DNA, Viral/*ANALYSIS
       Hepatitis B Surface Antigens/ANALYSIS  Human  HIV/*ISOLATION & PURIF
       HIV Core Protein p24/ANALYSIS  HIV Infections/EPIDEMIOLOGY
       Lymphocytes/*MICROBIOLOGY  Risk Factors  MEETING ABSTRACT

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