Document 3125
 DOCN  M94A3125
 TI    Is HIV disease progression influenced by CMV co-infection? SEROCO Study
       Group.
 DT    9412
 AU    Salmon-Ceron D; Colasante U; Carre N; Deveau C; Persoz A; Rouzioux C;
       Bucquet D; Service de Medecine Interne, Hopital Cochin 27, Paris,
       France.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):148 (abstract no. PB0018). Unique
       Identifier : AIDSLINE ICA10/94369450
 AB    OBJECTIVE: To determine whether CMV seropositivity or CMV seroconversion
       accelerates HIV disease progression in a French cohort (SEROCO) of
       non-hemophiliac HIV-infected adult patients with known date of
       infection. METHODS: The date of HIV infection was the mid-point of a
       maximum two years interval between HIV-/HIV+ serology, or the date of a
       well documented HIV primary infection (n = 567). CMV infection (CMV+)
       was defined by the presence of IgG antibodies at first visit (ELISA) and
       CMV seroconversion (Sero-CMV) by the occurrence of CMV antibodies at a
       biannual visit among initially negative patients (n = 83). Firstly, CMV+
       (n = 501) were compared to persistently CMV negative patients (CMV-) (n
       = 66). Secondly, Sero-CMV (n = 17) were compared to CMV-. End points
       were the occurrences of CDC group IV manifestations, an AIDS-defining
       illness or CD4+ count < 200/mm3. Cox model was used to quantify the
       relative risk (RR) before and after adjustement for age at HIV infection
       as a quantitative variable. RESULTS: After a mean time of 53 months
       after HIV infection: TABULAR DATA, SEE ABSTRACT VOLUME. Adjusted for CMV
       infection, influence of age was significant whatever was the end-point.
       Using the Log-rank after adjustment for age no difference in disease
       progression was shown between sero-CMV and CMV-, for stage IV (p =
       0.56), occurrence of CD4+ < 200/mm3 (p = 0.80) and AIDS (p = 0.32).
       DISCUSSION AND CONCLUSION: Although some previous studies, mainly on
       haemophiliac patients, had led to inverse results, in this work,
       involving a larger number of patients, co-infection with CMV does not
       seem to influence significantly the HIV disease progression.
 DE    Acquired Immunodeficiency Syndrome/*PHYSIOPATHOLOGY  Adult  AIDS-Related
       Opportunistic Infections/*PHYSIOPATHOLOGY  Comparative Study
       Cytomegalovirus Infections/COMPLICATIONS/*PHYSIOPATHOLOGY  Human  HIV
       Seropositivity/*PHYSIOPATHOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).