Document 3127
 DOCN  M94A3127
 TI    Great disturbances of steroids excretion of AIDS patients.
 DT    9412
 AU    Socolov IA; Pokrovsky VV; Emelianov BA; Semenov VA; Yurin OG; Gruzdev
       BM; Institute of epidemiology-AIDS center, Moscow, Russia.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):148 (abstract no. PB0020). Unique
       Identifier : AIDSLINE ICA10/94369448
 AB    METHOD: The amount of 15 different steroids is measured in urine samples
       of AIDS patients. Samples are compared before and after Chorionic
       Gonadotropin (ChG) stimulation test: (1500 iu--3 days-1500 iu--2 days +
       urinary sampling). RESULTS: The whole amount of urine steroids is 1/5 of
       the normal value. Decrease is prominent for ethiocholanolone,
       androsterone, DHEA, pregnandiol, pregnantriol. Decrease is less for
       estrogens, testosterone, tetrahydrocortison and tetrahydrocortisol.
       Testosterone/epitestosterone ratio is increased. Reaction to ChG is
       poor. DISCUSSION: AIDS patients demonstrate hyporeactivity of steroids
       producing tissues. Their excretion of steroids with urine looks much
       more impaired than blood steroids level. CONCLUSION: Chorionic
       gonadotropin is perspective to restore impaired steroids metabolism of
       AIDS patients, which are endocrine patients in this aspect.
 DE    Acquired Immunodeficiency Syndrome/*URINE  Androgens/URINE
       Estrogens/URINE  Gonadotropins, Chorionic/DIAGNOSTIC USE  Human
       Pregnanes/URINE  Steroids/*URINE  MEETING ABSTRACT

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