Document 3130
 DOCN  M94A3130
 TI    HIV infection in women in Argentina five years observational study.
 DT    9412
 AU    Lupo S; Santarelli MT; Kneitschel R; Bortolozzi R; Navarret N; Taborda
       M; Hospital Centenario, University of Rosario, Argentina.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):147 (abstract no. PB0013). Unique
       Identifier : AIDSLINE ICA10/94369445
 AB    OBJECTIVE: to describe the epidemiology, clinical aspects and
       antiretroviral therapy in a group of HIV (+) in Rosario City, Argentina.
       MATERIAL: since 1988 until 9/93 a total of 87 HIV (+) women were
       followed in our institution. Median age was 26 range (15-55); 16%
       initial stage 4 (WHO Staging System); heterosexual transmission 67%,
       IVDU 31%, blood transfusion 2%; married 43%, single 44%, 59% had
       children, 3% pregnant women; 60% male sexual partners with positive
       serology; median baseline CD4 count 605 range (69-1192) and baseline
       lymphocytes count 1848 range (456-3350). Median event times were
       estimated from Kaplan-Meier curves. RESULTS: heterosexual transmission
       58/87 (67%) was the dominant route in our population. Nine (10%) of
       children had positive serology for HIV, one of them is dead. More
       frequent opportunistic infections more frequent were: PCP 17 (19%),
       Tuberculosis 8 (9%) and Cryptococcal meningitis 5 (6%). Forty-one pts
       received antiretroviral therapy: AZT (46%), DDI (3%) and AZT+DDC (11%),
       median time to treatment was 25 months (mo); estimated SV at 60 mo was:
       85% and 71% (p = 0.6789) for pts with or without therapy respectively.
       Twenty-nine (33%) pts progressed to stage 4 with a median time to
       progression of 42 mo and 10 pts died; estimated probability of survival
       was 74% at 60 mo. CONCLUSION: 47% of patients started antiretroviral
       therapy due to progression of HIV infection. Heterosexual transmission
       was the predominant way in this population. PCP was the most frequent
       complication and Tuberculosis (pulmonary 3, extrapulmonary 5) was the
       second opportunistic infection. There was no neoplastic complications.
 DE    Adolescence  Adult  Antiviral Agents/THERAPEUTIC USE  Female  Human  HIV
       Infections/*EPIDEMIOLOGY/MORTALITY/TRANSMISSION  Middle Age  Probability
       Sex Behavior  Survival Analysis  Time Factors  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).