Document 3139
 DOCN  M94A3139
 TI    Acute and sustained immunosuppression with HIV seroconversion.
 DT    9412
 AU    Gupta KK
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):145 (abstract no. PB0006). Unique
       Identifier : AIDSLINE ICA10/94369436
 AB    OBJECTIVE: Acute and sustained immunosupression with serious systematic
       opportunistic infection can occur immediately after HIV seroconversion.
       RESULTS: TABULAR DATA, SEE ABSTRACT VOLUME. CMV Colitis was confirmed by
       biopsy, Immunoperoxidase stain and 10-fold increase in CMV IgG titer.
       CONCLUSIONS: 1. HIV morbidity and mortality figures will become
       proportionately worse with increased prevalence of this mutant strain.
       2. DNA sequencing should be done on this strain, to find any exclusive
       mutant sequence, responsible for excessive virulence. It should be
       deleted or altered by genetic engineering to obtain possibly a benign
       viral strain, which could be helpful for vaccine research.
 DE    Antibodies, Viral/BLOOD  AIDS-Related Opportunistic
       Infections/*IMMUNOLOGY  Cytomegalovirus/IMMUNOLOGY/ISOLATION &
       PURIF/PATHOGENICITY  Cytomegalovirus Infections/IMMUNOLOGY  CD4-CD8
       Ratio  Human  HIV Antibodies/ANALYSIS  HIV Seropositivity/*IMMUNOLOGY
       IgG/BLOOD  *Immune Tolerance  *Leukocyte Count  Morbidity  T-Lymphocyte
       Subsets/IMMUNOLOGY  Virulence  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).