Document 3140
 DOCN  M94A3140
 TI    Natural history of HIV-infection in Bulgaria.
 DT    9412
 AU    Plochev KS; Dicov I; Duchovnicova T; Radinov A; Brankova J; Penkova K;
       Valcova I; Doganova I; M. M. A.-Centre of immunology, Sofia, Bulgaria.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):144 (abstract no. PB0003). Unique
       Identifier : AIDSLINE ICA10/94369435
 AB    OBJECTIVE: An analysis of the course of the HIV-infection in Bulgaria
       for the period 1986-93 was performed. METHODS: The patients were exposed
       to epidemiologecal, clinical, paraclinical and immunological analysis.
       The main methods used were flow cytometry, laser nephelometry, CAT,
       sonography, and standart clinical procedures. For statistical analysis
       was used a software product Microsoft Excel for Windows 5.0. RESULTS:
       For the period of investigation at least 4 mln bulgarians and 72000
       foreigners were tested. 124 HIV+ bulgarians/0.003% of the tested
       population/and 90 foreigners were found. 24 infected bulgarians
       developed a clinic of AIDS and 20 of them died. Clinical investigations
       showed that 68% of HIV-infected suffered of oportunistic infections,
       distributed as follow: 36%-bacterial, 28%-fungal, 20%-viral, and
       16%-parasitic infections. 6% developed neoplasias and 26% were
       asymptomatic. Mycobacterial and pneumocystis carinii infections were
       very rare. 84 HIV-infected were followed up by immunophenotyping.
       DISCUSSIONS AND CONCLUSIONS: 1. HIV-infections has spread with a low
       intensity in Bulgaria. 2. Epidemiological data showed that the infection
       is developed by African type. 3. It is viewed very high mortality on the
       base of late recognizing. 4. Clinical and immunological approach for
       control of the infection allow us to precisely define the clinical stage
       of the disease.
 DE    Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY/MORTALITY/
       PHYSIOPATHOLOGY  AIDS-Related Opportunistic Infections/EPIDEMIOLOGY/
       PHYSIOPATHOLOGY  Bulgaria/EPIDEMIOLOGY  Comparative Study  Human  HIV
       Infections/COMPLICATIONS/*EPIDEMIOLOGY/*PHYSIOPATHOLOGY  HIV
       Seropositivity/*EPIDEMIOLOGY/*PHYSIOPATHOLOGY  Neoplasms/COMPLICATIONS
       Prevalence  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).