Document 3141
 DOCN  M94A3141
 TI    Natural history of HIV infection in infected Haitians with known date of
       seroconversion.
 DT    9412
 AU    Deschamps MM; Pape JW; Johnson WD Jr
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):144 (abstract no. PB0002). Unique
       Identifier : AIDSLINE ICA10/94369434
 AB    OBJECTIVE: To determine the Natural history of HIV infection in
       seropositive heterosexuals with known date of seroconversion. METHODS:
       From 1987-1993, 19 individuals from 475 discordant couples
       seroconverted, based on CDC definition. Date of HIV seroconversion is
       midpoint between last HIV (-) and first HIV (+). They were evaluated
       clinically every 3 months with CD4 count every 6 months. The following
       endpoints were: 1. Development of symptomatic conditions (CDC definition
       category A and B). 2. AIDS. 3. Death. RESULTS: After a median follow-up
       period of 32 months 4/19 became symptomatic. The symptom-free period was
       15 months. Initial manifestations were: generalized lymphadenopathy in
       3, Herpes zoster in 1; 2/19 developed AIDS at a mean of 48 months (AIDS
       Latency period). The time period from seroconversion to death is 76
       months with an AIDS survival time of 28 months. Fifteen seroconverters
       remained free of symptom after a median follow-up time of 30 months:
       with CD4 count > 500 in 11 individuals, and < 475 in 4 individuals.
       CONCLUSION: After a median period of 32 months, 4/19 seroconverters
       became sick, 2/19 developed AIDS and died; the remainders are free of
       symptoms. This study in on-going and will be updated.
 DE    Acquired Immunodeficiency Syndrome/MORTALITY/*PHYSIOPATHOLOGY
       AIDS-Related Opportunistic Infections/PHYSIOPATHOLOGY  Female  Follow-Up
       Studies  Haiti  Herpes Zoster/COMPLICATIONS  Human  HIV
       Infections/*PHYSIOPATHOLOGY  HIV
       Seropositivity/MORTALITY/*PHYSIOPATHOLOGY  Male  Sex Behavior  Time
       Factors  T4 Lymphocytes/IMMUNOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).