Document 3146
 DOCN  M94A3146
 TI    Interaction of HIV and human herpesvirus 7 in a CD4+ T cell line.
 DT    9412
 AU    Yamada M; Kamiya T; Yoshida M; Matsuo Y; Ikuta K; Yamanishi K; Okuno T;
       Minowada J; Nii S; Dep. of Virol., Okayama Univ. Med. Sch., Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):142 (abstract no. PA0186). Unique
       Identifier : AIDSLINE ICA10/94369429
 AB    OBJECTIVE: Human Herpesvirus 7 (HHV-7), a new T-lymphotropic
       herpesvirus, is related to, but significantly different from HHV-6.
       HIV-1 and HHV-7, as well as HHV-6, are believed to share CD4+ T
       lymphocytes as major target cells, and, for this reason, we studied the
       interaction of HIV-1 and HHV-7 using a CD4+ T cell line. METHODS: A CD4+
       CD8+ cell line, SUP-T1, and a HIV carrier cell line established from
       SUP-T1 were tested for permissiveness to HHV-6 or HHV-7 replication.
       RESULTS: The SUP-T1 is to date the only cell line, among 10 CD4+ T cell
       lines, susceptible to the productive infection of HHV-7. Expression of
       the CD4 antigen was completely downregulated in the HIV-1 carrier cell
       line. While superinfection of HIV-1 carrier SUP-T1 cells with HHV-6 was
       readily accomplished, the same cells were completely resistant to
       superinfection with HHV7. Furthermore, treatment of SUP-T1 cells with
       anti-CD4 monoclonal antibodies inhibited the growth of HHV-7. On the
       other hand, HHV-7 carrier SUP-T1 cells were readily superinfected with
       HIV-1. DISCUSSION AND CONCLUSIONS: Resistance of HIV-1 carrier SUP-T1
       cells to HHV-7 is due to the absence of the CD4 antigen on the cell
       surface. HIV-1 and HHV-7 are supposed to use the same molecule, the CD4
       antigen, as the virus receptor.
 DE    Antigens, CD/*PHYSIOLOGY  Antigens, CD4/PHYSIOLOGY  Antigens,
       CD8/PHYSIOLOGY  Cell Line  Comparative Study  Herpesvirus 6,
       Human/*PHYSIOLOGY  Herpesvirus 7, Human/*PHYSIOLOGY  Human
       HIV-1/*PHYSIOLOGY  Superinfection
       T-Lymphocytes/IMMUNOLOGY/*MICROBIOLOGY  T4
       Lymphocytes/IMMUNOLOGY/*MICROBIOLOGY  *Virus Replication  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).