Document 3147
 DOCN  M94A3147
 TI    Host immune response in chlamydial cervicitis.
 DT    9412
 AU    Mittal A; Kapur S; Institute of Pathology, New Delhi, India.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):142 (abstract no. PA0189). Unique
       Identifier : AIDSLINE ICA10/94369428
 AB    OBJECTIVE: To study host immune responses in chlamydial cervicitis.
       METHODS: Cellular immune responses were studied in peripheral blood and
       compared with local immune responses to chlamydial elementary bodies in
       patients. RESULTS: No significant difference was noted in lymphoblast
       transformation to antigens (PPD and C. trachomatis) between the control
       group and patients with chlamydial cervicitis. Percent inhibition of
       IL-2 production in cervical secretions ranged from 59% to 84% while
       supernatants stimulated with PPD in these patients failed to show
       inhibition. There was no inhibition of IL-2 production in
       secretions/supernatants in C. trachomatis negative cases. Antichlamydial
       antibodies (IgG or IgM) was present in all and IgA in 3 C. trachomatis
       positive cases. DISCUSSION AND CONCLUSION: Local cell mediated immunity
       is impaired in patients of chlamydial cervicitis, however, antigen
       reactive T cells are present.
 DE    Antibodies, Bacterial/BIOSYNTHESIS/*BLOOD  Antibody Formation
       Cervicitis/*IMMUNOLOGY/MICROBIOLOGY  *Chlamydia trachomatis  Chlamydia
       Infections/*IMMUNOLOGY  Female  Human  IgG/BIOSYNTHESIS
       IgM/BIOSYNTHESIS/BLOOD  Immunity, Cellular  Interleukin-2/BIOSYNTHESIS
       T-Lymphocytes/*IMMUNOLOGY  MEETING ABSTRACT

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