Document 3162
 DOCN  M94A3162
 TI    Possible role of pregnancy-specific glycoprotein (PSG) in mother-child
       HIV infection transfer.
 DT    9412
 AU    Blinov VM; Resenchuk SM; Chirikova GB; Denisov SI; Zverev VV; Institute
       of Molecular Biology, Koltsovo, Novosibirsk, Russia.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):139 (abstract no. PA0177). Unique
       Identifier : AIDSLINE ICA10/94369413
 AB    More than 3 million women mostly in reproductive age were AIDS-infected
       in 1990. Vertical transfer of HIV from an infected pregnant woman to her
       child becomes the main source of AIDS patients. Revealing of those
       protective factors which provide the birth of a healthy child from the
       HIV-infected mother is one of the most burning questions now. PSG is the
       key pregnancy-associated protein produced by placenta and detectable in
       maternal serum on the 18th days after ovulation. Analysis of PSG
       structure has shown that it is closely related to the carcinoembryonic
       antigen (CEA) family. CEA has recently been shown to be an intercellular
       adhesion molecule; both PSG and CEA are members of the immunoglobulin
       superfamily, which includes proteins that are arranged in domains and
       have constant and variable regions. Besides, the immonoglobuline-like
       domains are present in the env envelope protein of HIV which also takes
       part in adhesion with cellular CD4 and CD2 receptors. We suggest that
       PSG can act as the receptor for HIV proteins and discuss the
       possibilities of both the protection providing the birth of a healthy
       child from the HIV-infected mother and the elaboration of the
       preparations which prevent the transfer of HIV infection to the child.
 DE    Adult  Antigens, CD/PHYSIOLOGY  Antigens, CD4/PHYSIOLOGY  Antigens,
       Differentiation, T-Lymphocyte/PHYSIOLOGY  Cell Adhesion  Female  Human
       HIV Infections/*PREVENTION & CONTROL/PHYSIOPATHOLOGY/  *TRANSMISSION
       Infant, Newborn  *Maternal-Fetal Exchange  Pregnancy  Pregnancy
       Complications, Infectious/*PHYSIOPATHOLOGY  Pregnancy-Specific beta
       1-Glycoprotein/*PHYSIOLOGY  Receptors, Immunologic/PHYSIOLOGY  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).