Document 3166
 DOCN  M94A3166
 TI    Increased risk for a second retroviral infection (SIV or STLV) for wild
       monkeys already infected by one retrovirus.
 DT    9412
 AU    Tuppin P; Durand JP; Maison P; Galat G; Galat-Luong A; Jeannel D; de The
       G; Unite d'Epidemiologie des Virus Oncogenes, Institut Pasteur,; Paris,
       France.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):138 (abstract no. PA0170). Unique
       Identifier : AIDSLINE ICA10/94369409
 AB    In Senegal, between 1981 and 1982, 215 monkeys were killed during a
       yellow fever control in Kedougou, and 177 were trapped between 1989 and
       1991 in Sine Saloum. There were 221 patas monkeys (PM) and 171 african
       green monkeys (AGM). Sera were screened for SIV by ELISA assay (HIV 1
       and HIV 2) and confirmed by WB using a SIV agm as antigen. For STLV,
       ELISA, IF assays and WB were used. SIV seroprevalence rates were 3.2%
       for PM and 38.6% for AGM, and for STLV, 22.2% and 35.6% respectively. In
       AGM an increase risk of seropositivity to SIV was associated with STLV
       positivity (RR = 4.3, p < 0.0001), and in PM in Kedougou an increase
       risk was also found with being seropositive to STLV (OR = 15.6 p =
       0.01). These increase risk remain present after adjustment on area, sexe
       and age, suggesting a dependance of infection between these two endemic
       simian retroviruses in two species with different social and sexual
       behaviors. Such SIV-STLV coinfections represent a model for HIV-HTLV
       coinfections in humans.
 DE    Aging  Animal  Cercopithecus aethiops  Comparative Study  Disease
       Models, Animal  Erythrocebus patas  Female  Human  HTLV
       Infections/COMPLICATIONS/EPIDEMIOLOGY/*VETERINARY  Male  *Monkey
       Diseases  Retroviridae Infections/COMPLICATIONS/EPIDEMIOLOGY/*VETERINARY
       Risk Factors  Senegal/EPIDEMIOLOGY  Sex Behavior, Animal  Sex Factors
       Simian Acquired Immunodeficiency Syndrome/COMPLICATIONS/  *EPIDEMIOLOGY
       Social Behavior  *SIV  *STLV  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).