Document 3173
 DOCN  M94A3173
 TI    Phylogenetic analysis of HTLV-I/II from Colombia, Chile and Ghana.
 DT    9412
 AU    Miura T; Zaninovic V; Cartier L; Osei-Kwasi M; Aysi NK; Tajima K; Sonoda
       S; Yamashita M; Igarashi T; Takehisa J; et al; Inst. for Virus Res.,
       Kyoto Univ., Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):136 (abstract no. PA0163). Unique
       Identifier : AIDSLINE ICA10/94369402
 AB    OBJECTIVE: To clarify the phylogenetic relation of HTLV in the world,
       some new isolates of HTLV-I/II from Colombia, Chile and Ghana were
       genetically analyzed and compared with other HTLV/STLV. METHODS:
       Phylogenetic tree was constructed from nucleotide sequence of the part
       of LTR amplified by PCR. RESULTS: All 8 isolates (7 Colombia and 1
       Chile) of HTLV-I from native inhabitants in South America belonged to
       subtype A in cosmopolitan type, which consisted of many Caribbean and
       some Japanese and Indian isolates. All 3 isolates from Ghana belonged to
       subtype C which consisted of West African and some Caribbean isolates.
       All 8 isolates of HTLV-II from native South American (7 Colombia and 1
       Chile) belonged to HTLV-IIb. HTLV-II from a native Ghanaian in West
       Africa belonged to HTLV-IIa. DISCUSSION AND CONCLUSIONS: Subtype A
       implied a connection of the native Caribbean and South American with
       Japanese and Indian, a possible migration of the lineage to the American
       continent via Beringia in the paleolithic period, or across the Pacific
       Ocean in the more recent time. Subtype C supported the connection
       between Caribbean and West Africa during the slave trade. HTLV-IIb was
       suggested to be endemic in native inhabitant of South America, while
       there is a possibility that HTLV-IIa is endemic in Africa although
       getting conclusion is premature.
 DE    Chile  Colombia  Comparative Study  Ghana  Human
       HTLV-I/CLASSIFICATION/*GENETICS/ISOLATION & PURIF  HTLV-I
       Infections/MICROBIOLOGY  HTLV-II/CLASSIFICATION/*GENETICS/ISOLATION &
       PURIF  HTLV-II Infections/MICROBIOLOGY  *Phylogeny  Polymerase Chain
       Reaction/METHODS  Repetitive Sequences, Nucleic Acid  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).