Document 3175
 DOCN  M94A3175
 TI    Genetic analyses of HTLV-I from India and newly identified endemic Loci,
       Iranian Mashhad and Russia.
 DT    9412
 AU    Yamashita M; Syrtsev A; Achiron A; Shohat B; Gurtsevitch V; Ishida T;
       Yamamoto N; Takehisa J; Igarashi T; Ibuki K; et al; Inst. Virus Res.,
       Kyoto Univ., Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):136 (abstract no. PA0162). Unique
       Identifier : AIDSLINE ICA10/94369400
 AB    OBJECTIVE: Recently, Mashhadi Jews immigrated from Iran to Israel and
       people in some part of Russia such as Saharin and Turkmenistan were
       reported to have high prevalences of HTLV-I. To clarify phylogenetic
       relations, HTLV-I newly isolated in these loci and India were compared
       with others reported previously. METHODS: A part of LTR sequences was
       amplified from DNA of seropositive subjects by PCR. Their proviral DNA
       were sequenced and phylogenetically analyzed. RESULTS: Phylogenetic
       analysis evidently showed that both Iranian jewish and Indian HTLV-I
       were included to subtype A of cosmopolitan type, which consists of those
       from Caribbean basin, Japan and South America. The isolates of Iran
       formed a distinct cluster in subtype A, while Indian isolates did not
       cluster. Sequence analysis of Russian samples are in progress and will
       be presented. DISCUSSION AND CONCLUSIONS: The isolates of Iran, India,
       Japan, Caribbean Basin and South America have the definite relation each
       other and subtype A is spread over a large area. This finding is
       interesting in elucidating the origin and evolution of HTLV-I.
 DE    Cluster Analysis  Emigration and Immigration  Evolution  Human
       HTLV-I/*GENETICS/*ISOLATION & PURIF  HTLV-I
       Infections/*EPIDEMIOLOGY/MICROBIOLOGY  India/EPIDEMIOLOGY
       Iran/ETHNOLOGY/EPIDEMIOLOGY  Israel/EPIDEMIOLOGY  Jews  Prevalence
       *Repetitive Sequences, Nucleic Acid  Russia/EPIDEMIOLOGY  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).