Document 3182
 DOCN  M94A3182
 TI    HTLV-I infection in healthy blood donors in Russia.
 DT    9412
 AU    Parfanovich M; Zuntova Yu; Vlshemirsky O; Plvovarova I; D.I. Ivanovsky
       Institute of Virology, Moscow, Russia.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):134 (abstract no. PA0157). Unique
       Identifier : AIDSLINE ICA10/94369393
 AB    1176 sera from the patients with the different forms of haemoblastosis,
       blood donors, people from Chernobyl-region, patients with haemophilia
       were studied in 1993. The presence of antibodies to HTLV-I in sera was
       determined by indirect ELISA on the basis of natural viral antigen and
       was confirmed by Western blot Du Pont and in ELISA-test on the basis of
       synthetic peptides. 15 sera with the positive results were revealed. The
       positive results were confirmed by Western blot in 4 cases from blood
       donors (3 sera contained the antibodies to p19 gag protein; 1--to p24
       gag protein, and 4--to gp46 env protein). 3 sera were negative and 8
       sera were uncertain (they contained antibodies only to gag
       proteins--p19, p24, p26, p28, p53 in different combinations). So the
       percentage of seropositive sera makes up approximately 0.34%. It is
       necessary to note that carefully selected sera were used for the studies
       that probably explains rather high percentage of infection.
 DE    *Blood Donors  Blotting, Western  Comparative Study  Enzyme-Linked
       Immunosorbent Assay  Gene Products, gag/IMMUNOLOGY
       Hemophilia/COMPLICATIONS  Human  HTLV-I Antibodies/BLOOD  HTLV-I
       Infections/BLOOD/DIAGNOSIS/*EPIDEMIOLOGY  Prevalence
       Russia/EPIDEMIOLOGY  Ukraine  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).