Document 3183
 DOCN  M94A3183
 TI    HTLV-I among native people of far eastern regions of Russia.
 DT    9412
 AU    Gurtsevitch V; Senyuta N; Stepina V; Yakovleva L; Syrcev A; Susova O;
       Pavlish O; Cancer Research Center, Moscow, Russia.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):134 (abstract no. PA0156). Unique
       Identifier : AIDSLINE ICA10/94369392
 AB    OBJECTIVE: To study HTLV-I prevalence among native people inhabiting Far
       Eastern Russia with special attention to Nivkhi people from Sakhalin
       intimately connected with Ainu people before 1945. The latters revealed
       high level of HTLV-I seroprevalence when have been tested in Hokkaido.
       METHODS: Two commercial screening tests as well as various confirmatory
       assays including WPs with recombinant gp46 env and p40 tax and PCR
       analysis were used to detect HTLV-I carriers. PCR was also employed to
       discriminate between HTLV-I and HTLV-II. RESULTS: 16 of 1809 native
       individuals tested were finally recognized as HTLV-I positive. Among
       them 14 were representatives of Nivkhi people (2.25%), 1--Orochi people
       (1.2%) and 1--Negidalian people (1%). The other 6 groups of native
       people were found to be negative. Important, 13 of 14 HTLV-I infected
       Nivkhi people were inhbitants of the same settlement (Nogliki) in
       Sakhalin (5.2%). Experiments indicated that HTLV-I rather than HTLV-II
       is present in infected individuals. CONCLUSIONS: This study clearly
       demonstrates that: a) Nivkhi people are most HTLV-I infected among
       different natives inhabiting Far Eastern regions of Russia, b) a cluster
       of HTLV-I infection is present among Nivkhi people in Sakhalin; and d)
       HTLV-I infected Nivkhi people revealed unusual pattern of virus-specific
       antibodies consisting in discrepancy between low immune response and
       high PCR positivity level.
 DE    Carrier State/EPIDEMIOLOGY  Cluster Analysis  Comparative Study
       Demography  Diagnosis, Differential  Ethnic Groups  Human
       HTLV-I/ISOLATION & PURIF  HTLV-I Infections/DIAGNOSIS/*EPIDEMIOLOGY
       HTLV-II/ISOLATION & PURIF  HTLV-II Infections/DIAGNOSIS/EPIDEMIOLOGY
       Polymerase Chain Reaction/METHODS  Prevalence  Russia/EPIDEMIOLOGY
       MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).