Document 3190
 DOCN  M94A3190
 TI    Maintenance of high virus load even after seroconversion in newborn cats
       acutely infected with feline immunodeficiency virus.
 DT    9412
 AU    Zheng YH; Tokunaga K; Shoda K; Nishino Y; Kishi M; Zhong Q; Asahi S;
       Ishihara C; Kanda M; Ikuta K; Inst. Immunol. Sci., Hokkaido Univ.,
       Sapporo, Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):132 (abstract no. PA0149). Unique
       Identifier : AIDSLINE ICA10/94369385
 AB    OBJECTIVE: As an animal model for HIV pediatric infection, we examined
       whether or not the time at which viral infection occurs is an important
       factor for FIV-induced pathogenesis. METHODS: Three newborn and two
       adult cats were intraperitoneally inoculated with FIV Petaluma
       strain-infected feline T-lymphoblastoid cells. Virus load and antibody
       response were kinetically compared between the infected newborn and
       adult cats. RESULTS: The virus genome number in peripheral blood
       mononuclear cells (PBMC) was progressively increased even after
       seroconversion in the infected newborn cats, whereas followed rapidly by
       apparent virus genome clearance after seroconversion in the infected
       adult cats. In addition, all the infected newborn cats developed
       symptom, such as respiratory disease and stomatitis, about two months
       after the infection. The co-cultures of PBMC with T cells showed that
       FIV in newborn cats were cytopathic even after seroconversion, whereas
       FIV in adult cats converted from cytopathic to less cytopathic phenotype
       after seroconversion. DISCUSSION AND CONCLUSION: FIV infection in
       newborn cats maintained high virus load with pathogenic potential,
       leading to rapid development of the disease. This might be due to T cell
       specific immunotolerance or T cell dysfunction.
 DE    Animal  Animals, Newborn  Cats  Cells, Cultured  Feline Acquired
       Immunodeficiency Syndrome/IMMUNOLOGY/  *PHYSIOPATHOLOGY  Genome, Viral
       Immune Tolerance  Immunodeficiency Virus, Feline/GENETICS/ISOLATION &
       PURIF/  *PHYSIOLOGY  Lymphocytes/IMMUNOLOGY/MICROBIOLOGY
       T-Lymphocytes/IMMUNOLOGY  Time Factors  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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