Document 3192
 DOCN  M94A3192
 TI    Involvement of B cell subpopulation in progression of murine
       retrovirus-induced immunodeficiency syndrome.
 DT    9412
 AU    Hitoshi Y; Numata F; Uehara S; Takatsu K; Dept. Immunol., Univ. Tokyo,
       Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):132 (abstract no. PA0147). Unique
       Identifier : AIDSLINE ICA10/94369383
 AB    OBJECTIVE, Infection of susceptible C57BL/6 (B6) mice with LP-BM5 MuLV
       leads to the development of the murine acquired immunodeficiency
       syndrome (MAIDS), which shows many similarities with human AIDS. It has
       been reported that B cells are required for the progression of MAIDS. In
       our previous study, X chromosome-linked immunodeficiency mice (XID),
       which lack functionally mature B cells, show delayed progression of
       MAIDS. However it is not clear what is the cellular mechanisms of
       impaired progression of MAIDS in XID mice. Here we report that XID mice
       developed MAIDS after transplantation of B cells from infected B6 mice.
       METHODS, We transplanted spleen cells, lymphnode cells or purified B and
       T cells from LP-BM5 MuLV-infected B6 mice into XID mice and analyzed the
       development of MAIDS-related symptoms such as lymphadenopathy,
       hypergamma-globulinemia and low responsiveness to LPS or ConA. RESULTS,
       MAIDS-related symptoms were observed in XID mice within 10 weeks after
       the transplantation. However, XID mice did not show any symptoms of
       MAIDS till at least 20 weeks after LP-BM5 MuLV injection. Expansion of B
       cells and CD4+Thy1- cells in lymphnodes, which is one of the
       characteristics of MAIDS, was observed in the transplanted XID mice.
       Then we transplanted purified T or B cells from virus-infected B6 mice
       to XID mice. The B cells induced MAIDS-related symptoms in XID mice more
       severely than unfractionated cells. In contrast, the T cells did not
       induce MAIDS in XID mice. DISCUSSION AND CONCLUSION, We conclude that B
       cells from virus-infected B6 mice play an important role in triggering
       the progression of MAIDS in XID mice. Now we are trying to define what
       kind of B cell subpopulation is required for triggering the disease.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY  Animal  B-Lymphocyte
       Subsets/*IMMUNOLOGY  B-Lymphocytes/IMMUNOLOGY  Comparative Study  Human
       Immunologic Deficiency Syndromes/GENETICS/IMMUNOLOGY  *Leukemia Viruses,
       Murine  Lymph Nodes/IMMUNOLOGY  *Lymphocyte Transfusion  Mice  Mice,
       Inbred C57BL  Mice, Mutant Strains  Murine Acquired Immunodeficiency
       Syndrome/*IMMUNOLOGY  Spleen/IMMUNOLOGY  T-Lymphocytes/IMMUNOLOGY  Time
       Factors  X Chromosome  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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