Document 3194
 DOCN  M94A3194
 TI    Sequence necessary for the pathogenicity of murine AIDS (MAIDS) virus.
 DT    9412
 AU    Ishimoto A; Kubo Y; Higo K; Kobayashi H; Hirama T; Institute for Virus
       Research, Kyoto University, Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):131 (abstract no. PA0143). Unique
       Identifier : AIDSLINE ICA10/94369381
 AB    OBJECTIVE: It was examined whether the unique sequences of defective
       murine AIDS virus in its gag p15 and p12 regions are responsible for the
       development of MAIDS. METHODS: Recombinant viruses by replacing various
       regions of the gag gene of nonpathogenic ecotropic virus, with those of
       the MAIDS virus were constructed and its pathogenicity was examined.
       RESULTS: Recombinant containing both unique sequences of the MAIDS virus
       were replication defective and pathogenic. However, a recombinant
       containing either the gag p15 or p12 region of the MAIDS virus was
       replication defective and nonpathogenic. DISCUSSION AND CONCLUSION: The
       gag p15 and p12 regions of the MAIDS virus do not function as those of
       replication-competent viruses, and that both of the unique sequences in
       the gag p15 and p12 regions are required to develop MAIDS.
 DE    Animal  Base Sequence  Defective Viruses/GENETICS/PHYSIOLOGY  Gene
       Products, gag/*BIOSYNTHESIS  *Genes, gag  Mice  Murine Acquired
       Immunodeficiency Syndrome/*MICROBIOLOGY  Recombination, Genetic
       Retroviridae/*GENETICS/PHYSIOLOGY/*PATHOGENICITY  Virus Replication
       MEETING ABSTRACT

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