Document 3196
 DOCN  M94A3196
 TI    Dynamics of CD4 and CD8 cells in blood and lymph nodes of SIVmac239
       infected monkeys.
 DT    9412
 AU    Murayama Y; Mukai R; Matui K; Sata T; Takasaka M; Noguchi A; Hassan MA;
       Hayami M; Yoshikawa Y; Tsukuba Primate Center for Medical Research, NIH,
       Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):131 (abstract no. PA0145). Unique
       Identifier : AIDSLINE ICA10/94369379
 AB    OBJECTIVE: The purpose of the investigation was to analyze the dynamic
       interaction between disease progression and lymphocyte subsets in the
       blood and lymph nodes (LN). METHODS: The time courses of changes in CD4
       subsets and CD4/CD8 ratios were compared in bioptic samples of the LN
       and blood from SIVmac239 infected rhesus and cynomolgus monkeys.
       RESULTS: Although an apparent decrease of CD4 cells, especially CD29high
       CD4 cells, was recognized in the blood. the percentages of CD4 cells and
       CD4/CD8 ratios in the LN did not decline but rather increased at several
       times after SIV infection. In the LN, the CD29lowCD45RAlow CD4 subset
       appeared after virus inoculation and became predominant as the lesions
       of the LN progressed. This uncommon CD4 subset was inhibited from
       circulating to the periphery, resulting in a deficiency of the CD29high
       and CD45RAhigh CD4 cell pool in the LN. DISCUSSION AND CONCLUSIONS:
       These qualitative changes of the CD4 cells in the LN might be one of the
       reasons for the decline in circulating CD4 cells.
 DE    Animal  Antigens, CD8/BLOOD/*PHYSIOLOGY  CD4-CD8 Ratio  Lymph
       Nodes/*IMMUNOLOGY  Macaca fascicularis  Macaca mulatta  Simian Acquired
       Immunodeficiency Syndrome/BLOOD/*IMMUNOLOGY  SIV/*IMMUNOLOGY
       T-Lymphocyte Subsets/IMMUNOLOGY  T-Lymphocytes/*IMMUNOLOGY  T4
       Lymphocytes/*IMMUNOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).