Document 3198
 DOCN  M94A3198
 TI    The effect of glycyrrhizin in mice infected with murine retrovirus. I.
       Prevention of the progression of disease.
 DT    9412
 AU    Miyaji C; Watanabe H; Makino M; Abo T; Dep. of Immunol., Niigata Univ.
       Sch. of Medicine, Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):130 (abstract no. PA0139). Unique
       Identifier : AIDSLINE ICA10/94369377
 AB    OBJECTIVE: Glycyrrhizin (GL), one of the plant extracts, have been
       evaluated for their inhibitory effect on HIV replication. From these
       observations, we attempted to use GL in murine AIDS (MAIDS) model and
       evaluated the development of MAIDS. METHODS: C57BL/6 mice were
       inoculated with LP-BM5 MuLV. Treatment with GL was began 0 day or 4
       weeks after the virus inoculation, three times a week until 19 weeks.
       For monitoring the appearance of MAIDS, the spleen weight and axillary
       lymph node weight were measured. The immunological abnormalities were
       monitored with respect to the mitogenic response of spleen cells to Con
       A and LPS. Serum IgM levels were also determined. RESULTS: All mice
       infected with the virus alone developed MAIDS and died until 15 weeks
       after infection. GL had no effect on the 50% of mortality, although some
       mice that began the treatment on 4 weeks from virus inoculation were
       survived until 17 weeks. The splenomegaly and lymphadenopathy of mice
       treated GL were suppressed, compared with mice inoculated virus alone.
       The mice with no signs of disease had a normal Con A response, but did
       not show a LPS response. The mice with MAIDS had elevated levels of
       serum IgM. GL did not lower the levels of serum IgM even in these
       treated mice. CONCLUSIONS: These results suggested that the treatment of
       GL was considerably effective to MAIDS mice in preventing the
       progression of disease, although GL did not completely prevent their
       mortality.
 DE    Animal  Antiviral Agents/*THERAPEUTIC USE  Glycyrrhetinic Acid/*ANALOGS
       & DERIVATIVES/THERAPEUTIC USE  IgM/BLOOD  *Leukemia Viruses, Murine
       Lymph Nodes/DRUG EFFECTS/IMMUNOLOGY/PATHOLOGY  Lymphocyte Transformation
       Lymphocytes/DRUG EFFECTS/IMMUNOLOGY  Mice  Mice, Inbred C57BL  Murine
       Acquired Immunodeficiency Syndrome/IMMUNOLOGY/PATHOLOGY/  *PREVENTION &
       CONTROL  Spleen/DRUG EFFECTS/IMMUNOLOGY/PATHOLOGY  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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