Document 3200
 DOCN  M94A3200
 TI    A trial to establish a novel mouse model for AIDS.
 DT    9412
 AU    Yoshimoto T; Nagase H; Kojima K; Kanamori Y; Nariuchi H; Department of
       Allergology, Institute of Medical Science,; University of Tokyo, Japan.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):130 (abstract no. PA0141). Unique
       Identifier : AIDSLINE ICA10/94369375
 AB    OBJECTIVE: To try to establish a novel mouse model for AIDS, we analyzed
       various immunological parameters of DDD/1 mice subcutaneously injected
       with a mouse mammary tumor virus, MMTV (FM), which we have recently
       isolated and has strong superantigenic activity reacting to V beta 8.2+
       T cells. METHODS: After subcutaneous injection of MMTV (FM) into four
       footpads of DDD/1 mice, draining lymph nodes and spleen were analyzed at
       a given time for their cell number, composition of subsets and mitogenic
       response against anti-CD3 antibody. Histological analysis of these
       tissues was also performed. RESULTS: The draining lymph nodes gradually
       became enlarged approximately 10-30 times in size and the percentage of
       V beta 8.2+ T cells reached to around 50% in CD4+ T cells by 3 week
       after the injection. Spleen also became enlarged approximately 5-folds
       bigger than control by 6 weeks after the injection. The mitogenic
       response of spleen obtained from mouse injected with MMTV (FM) was
       significantly reduced compared to that of control. DISCUSSION AND
       CONCLUSIONS: The subcutaneous injection of MMTV (FM) into footpads of
       DDD/1 mice was revealed to induce lymphoadenopathy, splenomegaly and
       depressed immune response. Although further studies are currently in
       progress, these results suggest that DDD/1 mice injected with MMTV (FM)
       have a potential to be used as a novel mouse model for AIDS.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/PATHOLOGY  Animal
       Comparative Study  Disease Models, Animal  Lymph
       Nodes/IMMUNOLOGY/PATHOLOGY  Lymphocyte Subsets/IMMUNOLOGY  Lymphocyte
       Transformation  Mammary Tumor Viruses, Mouse/*PATHOGENICITY  Mice  Mice,
       Inbred Strains  Reference Values  Spleen/IMMUNOLOGY/PATHOLOGY
       Splenomegaly  MEETING ABSTRACT

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