Document 3212
 DOCN  M94A3212
 TI    Clonal deletion versus clonal anergy-facts and controversies.
 DT    9412
 AU    Salam A; Waer M; Vandeputte M; Rega Institute, Leuven, Belgium.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):128 (abstract no. PA0133). Unique
       Identifier : AIDSLINE ICA10/94369363
 AB    The present study was undertaken to investigate the role of viral
       superantigen in the process of clonal deletion and anergy in an
       immuno-suppressed state in an animal model in which M1sla acted as super
       antigen. HIV is reported recently to express a superantigenic characters
       which are responsible for clonal anergy and depletion of CD4+ T cells
       bearing VB domain. C3H(H2k,Thy1.2+,M1sla-) and AKR(H2k,Thy1.1+,M1sla+)
       mice were administered a fractionated dose of Total Lymphoid Irradiation
       (TLI) as a method of immuno-suppression since TLI is known as a potent
       immuno-suppressive regimen. TLI treated animals were given either 15 or
       30 x 15(6) Bone Marrow cells. When high numbers of donor cells were
       infused clonal anergy developed (5% VB remained). When low numbers of
       donor cells were infused clonal deletion occured (1% VB remained) as
       detected by Flow Cytometry. Recently it was suggested that AIDS
       pathogenesis was related significantly to perturbation of TCR VB domain
       in HIV infected subjects. Since HIV-1 is a retrovirus and AIDS as well
       as HIV infection involve same CD4+ T cells expressing VB TCR
       predominantly, it would be good to say that molecules suggestive of
       superantigenic features expressed by retrovirus might play a role in
       inducing tolerance by clonal deletion or anergy during HIV infection. In
       conclusion, though clonal deletion is the main mechanism used by
       superantigen for cell depletion in a normal state, both deletion and
       anergy contribute a role in an altered state.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY  Animal  Bone Marrow
       Transplantation/*IMMUNOLOGY  Flow Cytometry  Human  HIV
       Infections/IMMUNOLOGY  Immunosuppression/METHODS  *Lymphocyte Depletion
       Lymphocytes/*IMMUNOLOGY/RADIATION EFFECTS  Mice  Mice, Inbred AKR  Mice,
       Inbred C3H  Whole-Body Irradiation  MEETING ABSTRACT

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