Document 3225
 DOCN  M94A3225
 TI    The role of nitric oxide in patients with HIV-1 infection.
 DT    9412
 AU    Torre D; Ferrario G; Bonetta G; Zeroli C; Giola M; Fiori GP; Div.
       Infectious Diseases, Varese, Italy.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):124 (abstract no. PA0114). Unique
       Identifier : AIDSLINE ICA10/94369350
 AB    OBJECTIVE: Nitric oxide (NO) and its intermediates, nitrite and nitrate,
       exert microbiostatic and microbicidal effects against protozoa, fungi,
       bacteria and some viruses, including herpes simplex virus. NO modulates
       immune responses by mediating the regulation of lymphocyte proliferation
       and it influences local inflammatory reactions by altering adherence of
       neutrophils to endothelial surfaces. METHODS: Serum and bronchoalveolar
       lavage fluid levels of nitrite were measured colorimetrically by the
       Griess reaction, the absorbance was read at 550 nm. Data are expressed
       as micromoles of nitrite/liter. RESULTS: Normal levels of NO was noted
       in the sera of asymptomatic seropositive patients, in patients with
       HIV-1 encephalopathy, with cryptococcal meningitis, and in those with
       lymphoma. In contrast, increased levels of NO were noted in the sera
       (26.1 +/- 23.7 mumol/L; P < .0001) and in the bronchoalveolar lavage
       fluid (0.2 +/- 0.3 mumol/L; P = .0071). DISCUSSION AND CONCLUSIONS: It
       is likely that NO is produced in the lung during different processes,
       including host defense. NO may play a role in pulmonary cell-to-cell
       interactions and critical defense mechanisms of the host, in particular
       against opportunistic pathogens such as Pneumocystis carinii and
       Micobacterium sp.
 DE    Acquired Immunodeficiency Syndrome/BLOOD/COMPLICATIONS/  *METABOLISM
       AIDS Dementia Complex/BLOOD  AIDS-Related Opportunistic Infections/BLOOD
       Bronchoalveolar Lavage Fluid/CHEMISTRY  Comparative Study  Human  HIV
       Seropositivity/BLOOD  *HIV-1  Lymphoma/BLOOD/COMPLICATIONS  Meningitis,
       Cryptococcal/BLOOD  Nitric Oxide/ANALYSIS/BLOOD/*PHYSIOLOGY
       Nitrites/ANALYSIS  Reference Values  Spectrophotometry/METHODS  MEETING
       ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).