Document 3252
 DOCN  M94A3252
 TI    Chromosome studies of HIV-infected and uninfected cell lines and blood
       lymphocytes.
 DT    9412
 AU    Manolov G; Argirova R; Manolova Y; Central AIDS Lab., Sofia, Bulgaria.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):119 (abstract no. PA0097). Unique
       Identifier : AIDSLINE ICA10/94369323
 AB    OBJECTIVE: To study in vitro a possible chromosome aberrational role of
       HIV. METHODS: A chromosome analysis of two cell systems was carried out:
       1) peripheral blood lymphocytes (PBL)-uninfected and infected with HIV
       from H9/HTLV-IIIB of 5 healthy donors and 2/H9/HTLV-IIIB cells and their
       uninfected variant. RESULTS: Altogether 2965 mitoses from PBL and H9
       cultures--infected and uninfected--were analysed. No well-expressed
       aberrations in infected and uninfected cells but decreased mitotic index
       were found. Data suggest cytotoxic elimination of heavily affected
       mitoses in the infected cultures which corresponds with improved quality
       of chromosome plates. DISCUSSION AND CONCLUSION: The exhibited minimal
       chromosome aberrational effectivity of HIV is considered as a lysis of
       the most impaired and aberrant cells. The substantional difference of
       aberrations in vitro to aberrations in homosexuals (G. Manolov et al.,
       AIDS Res., 1984, 157) is rendered to opportunistic infections, lifestyle
       or to other HIV variants.
 DE    Cell Line  Cells, Cultured  *Chromosome Aberrations  Comparative Study
       Human  HIV/*PHYSIOLOGY  Lymphocytes/*CYTOLOGY/MICROBIOLOGY  Mitosis
       MEETING ABSTRACT

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