Document 3259
 DOCN  M94A3259
 TI    Modeling HIV pathogenesis using artificial life concepts and methods.
 DT    9412
 AU    Baehr M; Mind Designs, New York, NY.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):117 (abstract no. PA0087). Unique
       Identifier : AIDSLINE ICA10/94369316
 AB    OBJECTIVE: To develop a computer simulation of HIV pathogenesis using
       concepts and methods from artificial life research in order to enhance
       understanding of the complexity and variability of immune system/HIV
       interactions. METHODS: A database including 50 cell types and 10 HIV
       strain types with 60 pseudogenes each. Pseudogenes for cell surface
       receptor distribution, cytokine generation and effector thresholds as
       well as behavior repertoires are included. Simulation components include
       a pseudogene designer, a phenotypic tissue generator, a behavior
       modeling module, a results/fitness evaluator, and a
       reproduction/evolution algorithm. Software products include Microsoft
       Excel and Maxis SimLife. RESULTS: The model generates phenotypically
       representative 'cells' and simulates individual cell behavior based on
       rules for movement, attraction, cytokine production and surface receptor
       distribution. The model also creates cell ecology regions (lymph node,
       blood, etc.) and has the ability to generate different ecology types
       based on input variables. (CD4 T-cell count, HIV strain variability,
       co-factors, etc.)
 DE    Algorithms  *Computer Simulation  Cytokines/BIOSYNTHESIS  Databases,
       Factual  Human  HIV/GENETICS/*PATHOGENICITY  HIV
       Infections/*ETIOLOGY/IMMUNOLOGY/MICROBIOLOGY  *Models, Biological
       Pseudogenes  Receptors, Cell Surface/GENETICS/METABOLISM  Tissue
       Distribution  MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).