Document 3266
 DOCN  M94A3266
 TI    Probably reasons of hypervariability by AIDS.
 DT    9412
 AU    Deichman AM; Cancer Research Centre, Moscow, Russia.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):115 (abstract no. PA0080). Unique
       Identifier : AIDSLINE ICA10/94369309
 AB    OBJECTIVE: Any information (especially new) about AIDS is important.
       There aren't whole universal picture (even scetch) about nature,
       reasons, mechanisms for hypervariability formation by AIDS in biopshere.
       METHODS: theoretical reseaches show the main mechanisms of hypothetical
       concept may be two: IERT-individual epitope reverse translation (when
       there are non-single aminonucleic correspondence for genetic
       code--including mutations of different genes); and transfer of special
       vector-like nucleic sequences (VLNS-transfer) with nucleic equivalent of
       concrete epitope into. RESULTS: we know specific immune responce need
       the cognate physical contact between antigenpresentative cell
       (macrophage) and T-help, T-T and T-B cell's analogic contacts.
       DISCUSSION: supposedly both mechanisms are used by immune responce.
       Cross of strategic ways (in the same cells macrophages, T-help,
       anothers) for immune responce formation and viruse spreading (the
       first); and use the same hypothetical mechanisms (IERT and
       VLNS-transfer-the second) probably lead to hypervariability by AIDS.
       This mechanisms perhaps can exploit for diversity formation by different
       normal and pathologic processes (antibody formation, drug resistance,
       etc.).
 DE    Acquired Immunodeficiency Syndrome/*ETIOLOGY/IMMUNOLOGY/  MICROBIOLOGY
       Antigenic Determinants/GENETICS  B-Lymphocytes/IMMUNOLOGY  Human
       HIV/GENETICS/IMMUNOLOGY  HIV Antigens/GENETICS  Macrophages/IMMUNOLOGY
       Models, Biological  T-Lymphocytes/IMMUNOLOGY  Translation, Genetic
       Variation (Genetics)  MEETING ABSTRACT

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