Document 3328
 DOCN  M94A3328
 TI    Possible role of HIV gp120 in CD2/LFA-3 activation pathway.
 DT    9412
 AU    Blinov VM; Resenchuk SM; Denisov SI; Chirikova GB; Zverev VV; Institute
       of Molecular Biology, Koltsovo, Novosibirsk, Russia.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):100 (abstract no. PA0019). Unique
       Identifier : AIDSLINE ICA10/94369247
 AB    The CD2 molecule belongs to a family of cell-surface glycoproteins that
       function as adhesion molecules in the immune system. Human CD2 is found
       exclusively on cells of the T lineage: peripheral T lymphocytes, NK
       cells, and thymocytes. CD2 binds specifically to the surface
       glycoprotein LFA-3. More importantly, CD2/LFA-3 adhesion functions in
       the immune system to augment T cell activation; it initiates conjugate
       formation between participating T cells and antigen-presenting cells.
       Molecular mimicry between T-cell receptors and viral HIV proteins has
       been suggested as a possible cause of initiation or continuation of the
       autoimmune reaction in HIV infection. Search for the possible homologies
       between the HIV proteins within cellular protein sequences database
       revealed high similarity level with the LFA-3. The region of homology
       with LFA-3 proved to be the amino-terminal portion of gp 120, which may
       be a part of the site for interaction with cellular receptor CD2. The
       deduced amino acid sequence of the immunoglobulin-like domain in
       NH2-terminal of gp 120 reveals the conservation of typical features of
       immunoglobulin-like domain in the proteins of immunoglobulin
       superfamily.
 DE    Antigens, CD/GENETICS/*PHYSIOLOGY  Antigens, Differentiation,
       T-Lymphocyte/*PHYSIOLOGY  Binding Sites/GENETICS  Cell Adhesion
       Molecules/GENETICS/PHYSIOLOGY  Conserved Sequence  Human  HIV Envelope
       Protein gp120/GENETICS/*PHYSIOLOGY  HIV
       Infections/IMMUNOLOGY/MICROBIOLOGY  HIV-1/GENETICS/*PHYSIOLOGY  Membrane
       Glycoproteins/GENETICS/*PHYSIOLOGY  Receptors, Immunologic/*PHYSIOLOGY
       Sequence Homology, Amino Acid  T-Lymphocytes/IMMUNOLOGY/MICROBIOLOGY
       MEETING ABSTRACT

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