Document 3335
 DOCN  M94A3335
 TI    Differences in immune function among patients infected with distinct
       Thailand HIV-1 strains.
 DT    9412
 AU    Weniger BG; Tansuphaswadikul S; Young NL; Pau CP; Lohsomboon P;
       Yindeeyoungyeon W; Limpakarnjanarat K; Division of HIV/AIDS (E-50), CDC,
       Atlanta, Georgia 30333.
 SO    Int Conf AIDS. 1994 Aug 7-12;10(1):10 (abstract no. 012C). Unique
       Identifier : AIDSLINE ICA10/94369240
 AB    INTRODUCTION: Thai HIV-1 genotype A/subtype E and genotype B/subtype B
       circulate widely in Thailand, with A spread most often by sex and B
       predominant among IDUs. METHODS: Among symptomatic HIV+ Bangkok
       outpatients (n = 60) and inpatients (n = 267) from 8/91-9/92, 216 A and
       73 B infections were serotyped and compared. RESULTS: Of 162 sexual
       risk-group patients, 99% (160) had genotype A, while 86% (66) of 77 IDUs
       had B. Type As had lower mean CD4+ levels (204/microL, 11.4%) than Bs
       (310/microL, 20.0%, p < .001). CD4+ cells < 200/microL or < 14% occurred
       in 64% (133/209) of As and 44% (31/71) of Bs (p = .003). All 17
       Pneumocystis diagnoses were in As (p < .01), as were all 34 non-Candida
       mycoses (p < .001). However, TB occurred less often in As (33%) than Bs
       (53%, p = .002). Inpatient mortality rate was 20% among As and 12% among
       Bs (p = .14). Regression and classification tree analyses among men
       21-49 (to avoid sex and age confounding) found A independently
       associated with lower CD4+ levels, and not confounded by risk group. The
       differing opportunistic conditions, however, appeared to be mediated by
       the CD4+ levels. CONCLUSION: Different pathophysiologic manifestations
       of viral phenotype in patients with distinct HIV-1 strains may
       contribute to the segregation of strain by risk group.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/MICROBIOLOGY/
       TRANSMISSION  Adult  AIDS-Related Opportunistic Infections/DIAGNOSIS
       Female  Genotype  Human  HIV-1/GENETICS/*IMMUNOLOGY  Male  Middle Age
       Serotyping  Sexually Transmitted Diseases/MICROBIOLOGY  Substance Abuse,
       Intravenous/COMPLICATIONS  Thailand/EPIDEMIOLOGY  T4 Lymphocytes
       MEETING ABSTRACT

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).