TI: Ozone Therapy - The Underlying Therapeutical Concept and Models of Efficacy DT: April 1991 AU: Renate Viebahn-Hansler SO: Erfahrungsheilkunde, Vol. 40, No. 4, April 1991 AB: Due to its very specific reaction, medical ozone, as a pharmaceutical agent, has an accurately defined range of efficacy - and this in contrast to all known oxygen therapies. According to the dosage and concentration range, we make use of the different properties of ozone, i.e.: its germicidal action (by oxidative destruction), its ability to inactivate microorganisms, and its restitutional effect (at a low concentration range). This involves three major indications: external ulcers and severe skin lesions, diseases of viral and bacterial origin, and arterial circulatory disturbances. The restitutional effect of ozone can be understood via its oxidative influence on the oxygen metabolism, the induction of specific enzymes and the activation of immunocompetent cells.