TI: Rationale For Treatment of Cancer with Ozone DT: 1988 AU: Boguslaw Lipinski, Ph.D. SO: Boston Cardiovascular Health Center and Tufts University School of Medicine One Washington Street, Wellesley, MA. 02181 AB: The hypothesis is presented according to which cellular aging and divisions are controlled by the levels of oxygen and natural antioxidants (AOs). Normal homeostasis is characterized by optimal concentration of both factors. In cancer there is an abnormally high concentration of artificial, food-derived AOs and low oxygen supply. Under such conditions there is no lipid peroxidation products formed and thus no inhibitors are present to control cell division. This situation, similar to that occurring in the anaerobic cells can be reversed by introduction of strong oxidants such as oxygen or ozone in the presence of sufficient concentration of natural antioxidants (vitamin C and E). Intraarterial administration of ozone might, therefore, prove to be an effective treatment for many types of cancer.