TI:  Extra Corporeal Perfusion of Blood with Ozone-Oxygen 
     Mixtures in the Treatment of Hypoxic States

DT:  Not Known

AU:  Sergey Petrovich Peretyagin

SO:  Centre of Ozonotherapy, Medical Institute, Nizhny Novgorod, 
     Russia.

AB:  Under the conditions of experimental models (hemorrhagic 
     shock according to Wiggers, clinical death, perfusion of 
     isolated heart) and also in patients with signs of hypoxy in 
     postoperation, postresuscitation periods, effectiveness of 
     auto blood treatment with ozone-oxygen mixture in 
     oxygenator, attached to large peripheral or main vessels, 
     was studied.  It is established that ozone influence on 
     blood, eliminating oxygen deficiency in the organism, 
     resulted in decrease of insufficiently oxidized products - 
     lactate, pyruvate, deficiency of bufer bases, products of 
     nitrous metabolism, reduction of pH medium.  Treatment of 
     large volumes of the patient's blood with ozone, side-by-
     side with moderate increase of free-radical POL reactions, 
     contributes to activation of anti-oxydation protection 
     enzymes / superoxiddysmutase and catalase / and also 
     mobilizes other mechanisms of endogen disintoxication.  
     Under ozone influence energopotential of tissue cells 
     raises: LDg and GI-6-Ph-Dg activity increases, glycolytic 
     and pentosophosphatic ways of glycose oxidation are 
     activized, the cycle of tricarbonic acids is intensified; 
     enzyme activity of the respiratory chain and conjugation of 
     the processes of oxidizing phosphorilation is restored.  
     Simultaneously with metabolic responses, and important role 
     in liquidation of hypoxic disorders belongs to reactions of 
     cardiorespiratory system: dp/dt, stroke volume and heart 
     work per minute, respiratory volume and oxygen assumption 
     increase, pulse rate and breath become infrequent.  
     Microcirculation was restored: gradients of perfused blood 
     pressure were increased and the gradient of rectum / cutis 
     temperature was decreased; as for morphologic and 
     ultrastructural organization of the vascular bed it became 
     optimized.