Document 0076
 DOCN  M9440076
 TI    Efficacy of CHOP and G-CSF combination treatment versus CHOP monotherapy
       in HIV-1 infected patient with NHL (Meeting abstract).
 DT    9404
 AU    Gori A; Ridolfo AL; Romaniello A; Franzetti F; Coppin P; Formenti T;
       Gervasoni C; d'Arminio Monforte A; Moroni M; Clinic of Infectious
       Diseases, Univ. of Milan, Italy
 SO    Biological Response Modifiers, 2nd International Congress. January
       29-31. 1993, San Diego, CA, p. 76, 1993.. Unique Identifier : AIDSLINE
       ICDB/94698348
 AB    Objective: To evaluate whether G-CSF and CHOP treatment in HIV-1
       infected patients with high-grade NHL allows a better adherence to the
       therapeutic schedule as compared to patients treated with CHOP alone.
       Methods: We evaluated retrospectively 6 patients treated with CHOP
       compared with 8 patients treated with CHOP associated with G-CSF (5
       g/kg/day sc from 8th to 21st day of each cycle). In each group, we
       evaluated the number of cycles, the pauses between cycles, the necessity
       of drug dosage reduction, the degree of leukopenia at nadir, the
       duration of neutropenia (ANC less than 1000/mm3), the days of fever and
       the number of infectious episodes. Results are presented in a table.
       Conclusions: These preliminary data show that the patients treated with
       the association of G-CSF and chemotherapy withstand a greater number of
       cycles of therapy, at full doses and regular pauses, experiencing a
       reduction of the days of neutropenia, fever and infectious episodes.
 DE    Antineoplastic Agents, Combined/ADVERSE EFFECTS/*THERAPEUTIC USE
       Cyclophosphamide/ADMINISTRATION & DOSAGE  Doxorubicin/ADMINISTRATION &
       DOSAGE  Fever/CHEMICALLY INDUCED/DRUG THERAPY  Granulocyte
       Colony-Stimulating Factor/*THERAPEUTIC USE  HIV
       Infections/COMPLICATIONS/*DRUG THERAPY  Human  Leukopenia/CHEMICALLY
       INDUCED/DRUG THERAPY  Lymphoma, Non-Hodgkin's/COMPLICATIONS/*DRUG
       THERAPY  Neutropenia/CHEMICALLY INDUCED/DRUG THERAPY
       Prednisone/ADMINISTRATION & DOSAGE  Vincristine/ADMINISTRATION & DOSAGE
       MEETING ABSTRACT

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