Document 0100
 DOCN  M9440100
 TI    Risk of other cancers following Kaposi's sarcoma: relation to acquired
       immunodeficiency syndrome.
 DT    9404
 AU    Biggar RJ; Curtis RE; Cote TR; Rabkin CS; Melbye M; Epidemiology and
       Biostatistics Program, National Cancer; Institute, Bethesda, MD.
 SO    Am J Epidemiol. 1994 Feb 15;139(4):362-8. Unique Identifier : AIDSLINE
       MED/94152639
 AB    To evaluate the risk of another cancer among persons who initially
       developed Kaposi's sarcoma, the authors used data from the Surveillance,
       Epidemiology, and End Results (SEER) program of the National Cancer
       Institute for the years 1973-1990. In persons under 70 years of age,
       4,946 cases of Kaposi's sarcoma were observed during the period
       1980-1990 (6,217 person-years of follow-up). On the basis of rates seen
       during the period prior to the epidemic of acquired immunodeficiency
       syndrome (AIDS), 169 cases were expected. Therefore, cases of Kaposi's
       sarcoma in this group were assumed to be AIDS-related, while cases
       occurring in older persons or during the 1970s were assumed to be
       non-AIDS-related. Rates were compared with the numbers of cases expected
       overall and by site on the basis of age-, sex-, and calendar
       year-specific rates from the SEER data. Among the 4,946 persons with
       AIDS-related Kaposi's sarcoma, the risk of developing non-Hodgkin's
       lymphoma through 1990 was increased 198-fold (95% confidence interval
       169-232). However, the risk of all other cancers was only marginally
       increased (1.5-fold; 95% confidence interval 0.95-2.3), a risk that was
       probably biased upward because of ascertainment and misclassification.
       Among 491 persons with non-AIDS-related Kaposi's sarcoma, the relative
       risk of all cancers, including non-Hodgkin's lymphoma, was 0.9 (upper
       95% confidence limit 1.2), and the risk of non-Hodgkin's lymphoma alone
       was 0.6 (upper 95% confidence limit 3.3). As of 1990, the risk of having
       another cancer following Kaposi's sarcoma was increased only in persons
       infected with human immunodeficiency virus, who were at high risk of
       non-Hodgkin's lymphoma but probably not of other cancers as a whole.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Adult  Aged  Female
       Human  Lymphoma, Non-Hodgkin's/*EPIDEMIOLOGY/ETIOLOGY  Male  Middle Age
       Neoplasms, Second Primary/*EPIDEMIOLOGY/ETIOLOGY  Risk Factors  Sarcoma,
       Kaposi's/*EPIDEMIOLOGY/ETIOLOGY  United States/EPIDEMIOLOGY  JOURNAL
       ARTICLE

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