Document 0108
 DOCN  M9440108
 TI    Speculations around the mechanism behind the action of peptide T in the
       healing of psoriasis: a minireview.
 DT    9404
 AU    Johansson O; Hilliges M; Talme T; Marcusson JA; Wetterberg L; Department
       of Histology and Neurobiology, Karolinska Institute,; Stockholm, Sweden.
 SO    Acta Derm Venereol (Stockh). 1993 Dec;73(6):401-3. Unique Identifier :
       AIDSLINE MED/94152177
 AB    Peptide T, the HIV envelope-derived fragment
       Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr, has already been used to successfully
       treat psoriatic patients without major side-effects. The underlying
       reason for the positive effect is, however, at present unknown. In the
       following minireview, we summarize today's knowledge regarding peptide
       T's interaction with other chemical messenger molecules, such as
       somatostatin, vasoactive intestinal polypeptide (VIP) and epidermal
       growth factor (EGF), within the human skin, and, finally, speculate
       about their relationship to each other. In summary, we believe that the
       clearance effect of peptide T on psoriasis will open up new avenues with
       regard to the concept of the pathogenesis of as well as the clinical
       attendance to this disease.
 DE    Amino Acid Sequence  Human  Molecular Sequence Data  Peptide
       T/*PHARMACOLOGY  Psoriasis/*PATHOLOGY  Support, Non-U.S. Gov't
       Vasoactive Intestinal Peptide/PHYSIOLOGY  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

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