Document 0121
 DOCN  M9440121
 TI    Requirement for CD8 beta chain in positive selection of CD8-lineage T
       cells.
 DT    9404
 AU    Nakayama K; Nakayama K; Negishi I; Kuida K; Louie MC; Kanagawa O;
       Nakauchi H; Loh DY; Howard Hughes Medical Institute, Washington
       University School of; Medicine, St. Louis, MO 63110.
 SO    Science. 1994 Feb 25;263(5150):1131-3. Unique Identifier : AIDSLINE
       MED/94151682
 AB    CD8 is either an alpha alpha homodimer or an alpha beta heterodimer,
       although most peripheral CD8-lineage T cells express only the CD8 alpha
       beta heterodimer. The physiological function of CD8 beta was elucidated
       with mice that were chimeric for the homozygous disruption of the CD8
       beta gene. The CD8 beta-1- T cells developed normally to CD4+CD8+ stage,
       but did not efficiently differentiate further, which resulted in few
       peripheral CD8+ T cells. The number of peripheral CD8+ T cells was
       restored by transfer of an exogenous CD8 beta gene into CD8
       beta-deficient T cells. Thus, CD8 beta is necessary for the maturation
       of CD8+ T cells.
 DE    Animal  Antigens, CD4/GENETICS  Antigens,
       CD8/CHEMISTRY/GENETICS/*PHYSIOLOGY  Cell Differentiation  Cell Line
       Chimera  CD4-CD8 Ratio  Histocompatibility Antigens Class I/METABOLISM
       Mice  Mice, Inbred C57BL  Mice, Knockout  Mutation  Phenotype
       Receptors, Antigen, T-Cell/METABOLISM  Support, Non-U.S. Gov't  Support,
       U.S. Gov't, P.H.S.  T-Lymphocyte Subsets/CYTOLOGY/*IMMUNOLOGY/METABOLISM
       Transfection  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).