Document 0140
 DOCN  M9440140
 TI    Combinatorially selected guanosine-quartet structure is a potent
       inhibitor of human immunodeficiency virus envelope-mediated cell fusion.
 DT    9404
 AU    Wyatt JR; Vickers TA; Roberson JL; Buckheit RW Jr; Klimkait T; DeBaets
       E; Davis PW; Rayner B; Imbach JL; Ecker DJ; ISIS Pharmaceuticals,
       Carlsbad, CA 92008.
 SO    Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1356-60. Unique Identifier :
       AIDSLINE MED/94151329
 AB    The phosphorothioate oligonucleotide T2G4T2 was identified as an
       inhibitor of HIV infection in vitro by combinatorial screening of a
       library of phosphorothioate oligonucleotides that contained all possible
       octanucleotide sequences. The oligonucleotide forms a parallel-stranded
       tetrameric guanosine-quartet structure. Tetramer formation and the
       phosphorothioate backbone are essential for antiviral activity. The
       tetramer binds to the human immunodeficiency virus envelope protein
       gp120 at the V3 loop and inhibits both cell-to-cell and virus-to-cell
       infection.
 DE    Antiviral Agents/*PHARMACOLOGY  Cell Fusion/*DRUG EFFECTS  Cells,
       Cultured  Dose-Response Relationship, Drug  Human  HIV Envelope Protein
       gp120/*METABOLISM  HIV-1/*DRUG EFFECTS/GROWTH &
       DEVELOPMENT/PATHOGENICITY  Oligodeoxyribonucleotides/CHEMICAL
       SYNTHESIS/METABOLISM/  *PHARMACOLOGY  Thionucleotides/CHEMICAL
       SYNTHESIS/METABOLISM/*PHARMACOLOGY  T4
       Lymphocytes/METABOLISM/MICROBIOLOGY  Virulence/DRUG EFFECTS  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).