Document 0146
 DOCN  M9440146
 TI    Bacillus Calmette-Guerin infection after vaccination of human
       immunodeficiency virus-infected children.
 DT    9404
 AU    Besnard M; Sauvion S; Offredo C; Gaudelus J; Gaillard JL; Veber F;
       Blanche S; Departement de Pediatrie, Hopital Necker Enfants, Malades,;
       Paris, France.
 SO    Pediatr Infect Dis J. 1993 Dec;12(12):993-7. Unique Identifier :
       AIDSLINE MED/94151113
 AB    The use of Mycobacterium bovis/Bacillus Calmette-Guerin (BCG) to
       vaccinate against tuberculosis remains controversial. The development of
       tuberculosis in human immunodeficiency virus (HIV)-infected children
       demands specific evaluation of the risk/benefit ratio of BCG vaccination
       in this situation. In our institution 9 of 68 HIV-infected children
       vaccinated with BCG before the diagnosis of HIV infection was suspected
       developed vaccine-related complications: 7 of these children had a large
       satellite adenopathy with or without skin fistulae, whereas the other 2
       had disseminated BCG infection beyond the satellite ganglion
       (involvement of the spleen and mesenteric and mediastinal lymph nodes in
       one case and the liver and lungs in the other). The children were
       vaccinated soon after birth; no particular problems were observed at
       that time, but complications appeared 3 to 35 months later. All but one
       of these children had a rapidly progressive form of HIV disease. The
       possibility of delayed local or disseminated BCG infection must be
       considered in analysis of the risk/benefit ratio of vaccination of
       HIV-infected children. The prognosis of HIV infection must be taken into
       account, even if the child is asymptomatic when vaccination is being
       considered.
 DE    BCG Vaccine/*ADVERSE EFFECTS  Human  HIV Infections/*COMPLICATIONS
       Infant  Infant, Newborn  *Mycobacterium bovis  Tuberculosis/*ETIOLOGY
       Vaccination/ADVERSE EFFECTS  JOURNAL ARTICLE

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