Document 0150
 DOCN  M9440150
 TI    A comparison of immunoglobulin G-containing high-molecular-weight
       complexes isolated from children with juvenile rheumatoid arthritis and
       congenital human immunodeficiency virus infection.
 DT    9404
 AU    Jarvis JN; Iobidze M; Taylor H; DeJonge J; Chang S; Division of
       Immunology/Rheumatology, Wayne State University; School of Medicine,
       Detroit, Michigan 48201.
 SO    Pediatr Res. 1993 Dec;34(6):781-4. Unique Identifier : AIDSLINE
       MED/94151079
 AB    Circulating immune complexes have been described in both juvenile
       rheumatoid arthritis and in AIDS. We isolated high-molecular-weight
       complexes from plasma of children with juvenile rheumatoid arthritis and
       congenital human immunodeficiency virus infection by sequential gel
       filtration followed by affinity chromatography on protein A-Sepharose.
       We demonstrate that 1) mixed IgG-, IgM-, and IgA-bearing immune
       complexes can be found in both juvenile rheumatoid arthritis and
       congenital human immunodeficiency virus infection and 2) complexes
       isolated via affinity chromatography on protein A-Sepharose do not have
       detectable C4 but activate the classic complement pathway in vitro.
 DE    Adolescence  Antigen-Antibody Complex/*BLOOD/CHEMISTRY/ISOLATION & PURIF
       Arthritis, Juvenile Rheumatoid/*IMMUNOLOGY  Child  Child, Preschool
       Chromatography, Affinity  Comparative Study  Complement Pathway,
       Classical  Complement 4/METABOLISM  Human  HIV
       Infections/CONGENITAL/*IMMUNOLOGY  IgA/BLOOD  IgG/*BLOOD  IgM/BLOOD  In
       Vitro  Infant  Molecular Weight  Peptide Fragments/METABOLISM
       Rheumatoid Factor/BLOOD  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).