Document 0179
 DOCN  M9440179
 TI    Disseminated active HHV-6 infections in patients with AIDS [see
       comments]
 DT    9404
 AU    Knox KK; Carrigan DR; Department of Pathology, Medical College of
       Wisconsin, Milwaukee; 53226.
 SO    Lancet. 1994 Mar 5;343(8897):577-8. Unique Identifier : AIDSLINE
       MED/94150175
 CM    Comment in: Lancet 1994 Mar 5;343(8897):555-6
 AB    Human herpesvirus 6 (HHV-6) infected cells were detected in all lung,
       lymph-node, spleen, liver, and kidney tissues obtained at necropsy from
       an unselected series of nine patients with AIDS. This infection rate was
       significantly higher than that for cytomegalovirus. Lung infection with
       HHV-6 was extensive enough in one patient to account for fatal
       pneumonitis. In other tissues increased numbers of HHV-6 infected cells
       were related to the presence of lymphocytes infiltrates or residual
       lymphoid tissue, with lymphocytes being predominantly infected. Thus
       HHV-6 is an important pathogen in patients with AIDS.
 DE    Acquired Immunodeficiency Syndrome/*MICROBIOLOGY  Autopsy  AIDS-Related
       Opportunistic Infections/*MICROBIOLOGY  Case-Control Studies
       Cytomegalovirus/ISOLATION & PURIF  Cytomegalovirus
       Infections/MICROBIOLOGY  Herpesviridae Infections/*MICROBIOLOGY
       Herpesvirus 6, Human/*ISOLATION & PURIF  Human  Male  Pneumonia,
       Pneumocystis carinii/MICROBIOLOGY  Pneumonia, Viral/MICROBIOLOGY
       Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).