Document 0219
 DOCN  M9440219
 TI    Induction of IL-1 beta, IL-6, TNF-alpha, GM-CSF and G-CSF in human
       macrophages by smooth transparent and smooth opaque colonial variants of
       Mycobacterium avium.
 DT    9404
 AU    Fattorini L; Xiao Y; Li B; Santoro C; Ippoliti F; Orefici G; Laboratory
       of Bacteriology and Medical Mycology, Istituto; Superiore di Sanita,
       Rome, Italy.
 SO    J Med Microbiol. 1994 Feb;40(2):129-33. Unique Identifier : AIDSLINE
       MED/94149666
 AB    Both smooth transparent (SmT) and smooth domed-opaque (SmD) colonial
       variants were obtained from a strain of Mycobacterium avium isolated
       from a patient with AIDS. The two variants showed similar biochemical
       characteristics but SmT bacteria proliferated better than SmD bacteria
       inside human macrophages and were much less capable than the SmD variant
       of inducing the release of IL-1 beta, IL-6, TNF-alpha, GM-CSF and G-CSF,
       after incubation for either 3 or 6 days. As cytokines are important
       extracellular signals for immune cells, the lack of induction observed
       in SmT-infected macrophages may be one of the pathogenic mechanisms of
       M. avium.
 DE    AIDS-Related Opportunistic Infections/MICROBIOLOGY  Cells, Cultured
       Culture Media  Cytokines/*BIOSYNTHESIS  Granulocyte Colony-Stimulating
       Factor/BIOSYNTHESIS  Granulocyte-Macrophage Colony-Stimulating
       Factor/BIOSYNTHESIS  Human  Interleukin-1/BIOSYNTHESIS
       Interleukin-6/BIOSYNTHESIS  Macrophages/IMMUNOLOGY/*MICROBIOLOGY
       Monocytes/IMMUNOLOGY/MICROBIOLOGY  Mycobacterium avium Complex/GROWTH &
       DEVELOPMENT/*IMMUNOLOGY  Mycobacterium avium-intracellulare
       Infection/MICROBIOLOGY  Peptide Fragments/BIOSYNTHESIS  Support,
       Non-U.S. Gov't  Tumor Necrosis Factor/BIOSYNTHESIS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
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