Document 0240
 DOCN  M9440240
 TI    Serum levels of tumor necrosis factor-alpha (TNF alpha) and soluble TNF
       receptors in human immunodeficiency virus type 1 infection--correlations
       to clinical, immunologic, and virologic parameters.
 DT    9404
 AU    Aukrust P; Liabakk NB; Muller F; Lien E; Espevik T; Froland SS; Section
       of Clinical Immunology and Infectious Diseases, Medical; Department A,
       Rikshospitalet, Oslo, Norway.
 SO    J Infect Dis. 1994 Feb;169(2):420-4. Unique Identifier : AIDSLINE
       MED/94149332
 AB    Two EIAs (Medgenix and Quantikine) and a bioassay were used to measure
       tumor necrosis factor-alpha (TNF alpha) in serum samples from 73 human
       immunodeficiency virus type 1 (HIV-1)-seropositive patients and in
       samples from 2 control groups. All clinical groups of HIV-1-infected
       patients, regardless of concurrent illness, had significantly elevated
       levels of both types of soluble TNF receptors (sTNFRs) and
       immunoreactive TNF alpha (Medgenix EIA), with the highest concentrations
       among the AIDS patients. These TNF parameters were significantly
       correlated with reduced CD4+ lymphocyte counts. Only a few
       HIV-1-infected patients had detectable TNF alpha levels measured by the
       Quantikine EIA. TNF alpha bioactivity was significantly raised only in
       the AIDS group. Serially measured sTNFRs, expressed as sTNFR slopes,
       were significantly associated with survival in the patient group. The
       raised levels of immunoreactive TNF alpha and sTNFRs strongly indicate
       activation of the TNF alpha system during HIV-1 infection. Levels
       increase with disease progression and degree of immunodeficiency; thus,
       serially measured sTNFRs may give useful prognostic information in HIV-1
       infection.
 DE    Adult  Biopterin/ANALOGS & DERIVATIVES/BLOOD  Human  HIV
       Infections/*BLOOD  HIV Seropositivity/BLOOD  Leukocyte Count  Receptors,
       Tumor Necrosis Factor/CHEMISTRY/*METABOLISM  Solubility  Support,
       Non-U.S. Gov't  Tumor Necrosis Factor/*METABOLISM  T4 Lymphocytes
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).