Document 0247
 DOCN  M9440247
 TI    Mycobacterium avium complex in the respiratory or gastrointestinal tract
       and the risk of M. avium complex bacteremia in patients with human
       immunodeficiency virus infection.
 DT    9404
 AU    Chin DP; Hopewell PC; Yajko DM; Vittinghoff E; Horsburgh CR Jr; Hadley
       WK; Stone EN; Nassos PS; Ostroff SM; Jacobson MA; et al; San Francisco
       General Hospital Medical Center, CA 94110.
 SO    J Infect Dis. 1994 Feb;169(2):289-95. Unique Identifier : AIDSLINE
       MED/94149312
 AB    Mycobacterium avium complex (MAC) is frequently isolated from the
       respiratory or gastrointestinal tract of patients with advanced human
       immunodeficiency virus (HIV) infection. Whether they are at increased
       risk of MAC bacteremia and whether culture of respiratory tract or stool
       specimens is useful for predicting bacteremia are unclear. HIV-infected
       patients with < or = 50 CD4+ cells/microL were prospectively studied.
       The risk of MAC bacteremia was approximately 60% within 1 year for
       patients with MAC in either the respiratory or gastrointestinal tract
       and was greater than for those without MAC in these sites (relative
       hazards for respiratory and gastrointestinal tract, 2.3 and 6.0; 95%
       confidence intervals, 1.1-4.6 and 2.5-14.6, respectively). Both
       respiratory tract specimen and stool culture had poor sensitivities (22%
       and 20%, respectively) but good positive predictive values
       (approximately 60%) for bacteremia. Symptomatic HIV-infected patients
       with MAC in the respiratory or gastrointestinal tract are at a
       substantial risk for developing MAC bacteremia; culture of these sites
       has limited usefulness as a screening test.
 DE    Adult  Feces/MICROBIOLOGY  Female  Gastrointestinal
       Diseases/*ETIOLOGY/MICROBIOLOGY  Human  HIV
       Infections/*COMPLICATIONS/IMMUNOLOGY  Leukocyte Count  Life Tables  Male
       Middle Age  Mycobacterium avium Complex/*PATHOGENICITY  Mycobacterium
       avium-intracellulare Infection/*ETIOLOGY/  MICROBIOLOGY  Prospective
       Studies  Respiratory Tract Diseases/*ETIOLOGY/MICROBIOLOGY  Risk Factors
       Support, U.S. Gov't, P.H.S.  T4 Lymphocytes  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).