Document 0249
 DOCN  M9440249
 TI    Strain specificity of cell-mediated cytotoxic responses specific for the
       human immunodeficiency virus type 1 (HIV-1) envelope protein in
       seropositive donors: HIV-1Lai is more commonly recognized than HIV-1MN.
 DT    9404
 AU    Robertson MN; Buseyne F; Kieny MP; Riviere Y; Unite de Virologie et
       Immunologie Cellulaire, Institut Pasteur,; Paris, France.
 SO    J Infect Dis. 1994 Feb;169(2):274-80. Unique Identifier : AIDSLINE
       MED/94149310
 AB    Cell-mediated cytotoxic (CMC) responses were measured in a group of
       human immunodeficiency virus type 1 (HIV-1)-seropositive donors against
       target cells expressing the envelope protein of either the HIV-1 strain
       Lai or strain MN. In primary CMC assays using freshly isolated
       peripheral blood mononuclear cells, seropositive individuals more
       commonly had CMC responses against HIV-1Lai than HIV-1MN. Moreover, each
       of the responders to HIV-1MN envelope also had primary CMC responses
       against HIV-1Lai envelope. Cytotoxic T cells generated by nonspecific in
       vitro stimulation recognized both strains at a similar frequency. These
       results may indicate the existence of multiple effector populations or
       that the cellular immune response is directed at regions of the envelope
       outside the V3 loop. By contrast, serologic studies done on similar
       populations have shown that most persons have antibodies capable of
       recognizing the V3 loop of HIV-1MN but rarely that of HIV-1Lai.
 DE    Cytotoxicity, Immunologic  Human  HIV Envelope Protein gp120/*IMMUNOLOGY
       HIV Seropositivity/*DIAGNOSIS  HIV-1/*CLASSIFICATION  Immunity, Cellular
       Immunologic Memory  Leukocyte Count  Recombinant Proteins/IMMUNOLOGY
       Species Specificity  Support, Non-U.S. Gov't  T4 Lymphocytes  JOURNAL
       ARTICLE

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