Document 0263
 DOCN  M9440263
 TI    Neonatal treatment with luteinizing hormone-releasing hormone analogs
       alters peripheral lymphocyte subsets and cellular and humorally mediated
       immune responses in juvenile and adult male monkeys.
 DT    9404
 AU    Mann DR; Ansari AA; Akinbami MA; Wallen K; Gould KG; McClure HM;
       Morehouse School of Medicine, Emory University School of; Medicine,
       Atlanta, Georgia 30310.
 SO    J Clin Endocrinol Metab. 1994 Feb;78(2):292-8. Unique Identifier :
       AIDSLINE MED/94149125
 AB    We examined the effect of treatment with a LH-releasing hormone (LHRH)
       agonist (Ag), antagonist (Ant), or Ant and androgen (Ant/And) for the
       first 4 months of postnatal life on lymphocyte subsets and cellular and
       humorally mediated immune responses in juvenile and adult male monkeys.
       We also determined the effect of 9 weeks of Ant treatment on lymphocyte
       subsets in adult male monkeys. Adult male monkeys that had been treated
       neonatally with an Ag had increased levels of CD8-positive (CD8+)
       T-cells and reduced levels of B-cells compared to vehicle-treated
       controls. Lymphocytes from these animals also showed an elevated
       proliferative response to a variety of mitogens compared to cells from
       control animals. Antibody production in response to tetanus toxoid was
       normal in treated animals. Other neonates treated with Ant/And exhibited
       subnormal levels of lymphocytes, CD8+ T-cells, and B-cells at 4 months
       of age. Similar changes, but of lesser magnitude, were observed in
       animals treated with Ant alone. At 6 months of age, lymphocytes from
       both groups of Ant-treated monkeys exhibited an above normal
       proliferative response to streptolysin-O, but not to other mitogens. At
       18 months of age, animals treated with Ant alone produced more
       antitetanus antibody in response to a tetanus toxoid booster than the
       controls or Ant/And-treated animals. Ant treatment was without major
       effect on lymphocyte subsets in adult monkeys. Serum LH and testosterone
       levels declined, and there was a small but significant increase in
       B-cells, lymphocytes expressing the interleukin-2 receptor, and the
       CD4+/CD8+ T-cell ratio during treatment, but these parameters normalized
       during the posttreatment period. The data suggest that chronic neonatal
       treatment with an Ag or Ant alters the development of immune system
       responses in male primates. The significance of these changes and their
       impact on the ability of these animals to respond to pathogenic agents
       is under investigation.
 DE    Aging/*IMMUNOLOGY/PHYSIOLOGY  Animal  Animals, Newborn  Antibody
       Formation/*IMMUNOLOGY  B-Lymphocyte
       Subsets/CYTOLOGY/IMMUNOLOGY/ULTRASTRUCTURE  Cell Count  Comparative
       Study  CD4-CD8 Ratio  Gonadorelin/*ANALOGS & DERIVATIVES/*PHARMACOLOGY
       Immune System/DRUG EFFECTS/PHYSIOLOGY  Immunity, Cellular/*IMMUNOLOGY
       Lymphocyte Subsets/*CYTOLOGY/*IMMUNOLOGY/PHYSIOLOGY  LH/BLOOD  Macaca
       mulatta/*IMMUNOLOGY  Male  Mitogens/PHARMACOLOGY  Receptors,
       Interleukin-2/ANALYSIS  Support, U.S. Gov't, P.H.S.  T-Lymphocyte
       Subsets/CYTOLOGY/IMMUNOLOGY/ULTRASTRUCTURE  Testosterone/BLOOD  JOURNAL
       ARTICLE

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